ArticleNature2014
GATM locus does not replicate in rhabdomyolysis study.
Abstract readLetterComment
In one paragraph
Article in Nature, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 6 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Correlation between single-nucleotide polymorphisms and statin-induced myopathy: a mixed-effects model meta-analysis.European journal of clinical pharmacology · 2021Pooled it
- The association of GATM polymorphism with statin-induced myopathy: a systematic review and meta-analysis.European journal of clinical pharmacology · 2021Pooled it
- Genomewide Association Study of Statin-Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink.Clinical pharmacology and therapeutics · 2019Pooled it
- Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing.PloS one · 2019Pooled it
- Role of genetics in the prediction of statin-associated muscle symptoms and optimization of statin use and adherence.Cardiovascular research · 2018Pooled it
- GATM polymorphism associated with the risk for statin-induced myopathy does not replicate in case-control analysis of 715 dyslipidemic individuals.Cell metabolism · 2015Pooled it
- GATM alleviates sepsis-induced acute kidney injury via PDK4-mediated glycolytic reprogramming in renal tubular epithelial cells.Cellular and molecular life sciences : CMLS · 2026Article
- Statin-Associated Myopathy: Emphasis on Mechanisms and Targeted Therapy.International journal of molecular sciences · 2021Review
- Identifying genetic modulators of statin response using subject-derived lymphoblastoid cell lines.Pharmacogenomics · 2021Review
- Effects of statins on mitochondrial pathways.Journal of cachexia, sarcopenia and muscle · 2021Review
- Robust Performance of Potentially Functional SNPs in Machine Learning Models for the Prediction of Atorvastatin-Induced Myalgia.Frontiers in pharmacology · 2021Article
- Pharmacogenetics of Statin-Induced Myotoxicity.Frontiers in genetics · 2020Review
- Statin-Related Myotoxicity: A Comprehensive Review of Pharmacokinetic, Pharmacogenomic and Muscle Components.Journal of clinical medicine · 2019Review
- Creatine as a Candidate to Prevent Statin Myopathy.Biomolecules · 2019Review
- Effects of SLCO1B1 and GATM gene variants on rosuvastatin-induced myopathy are unrelated to high plasma exposure of rosuvastatin and its metabolites.Acta pharmacologica Sinica · 2019Article
- RYR1 and CACNA1S genetic variants identified with statin-associated muscle symptoms.Pharmacogenomics · 2018Article
- The adjuvant value of Herba Cistanches when used in combination with statin in murine models.Scientific reports · 2017Article
- Patients experiencing statin-induced myalgia exhibit a unique program of skeletal muscle gene expression following statin re-challenge.PloS one · 2017Article
- Pharmacogenomics of statins: understanding susceptibility to adverse effects.Pharmacogenomics and personalized medicine · 2016Review
- Pharmacogenomics of hypertension and heart disease.Current hypertension reports · 2015Review
Corrections and comments
- Commented on by
- Comment on
Authors and funding
6 authors.
James S Floyd1] Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Suite 1360, Seattle, Washington 98101, USA [2] Department of Medicine, University of Washington, 1959 Northeast Pacific Street, Box 356420, Seattle, Washington 98195-6420, USA.
Joshua C Bis1] Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Suite 1360, Seattle, Washington 98101, USA [2] Department of Medicine, University of Washington, 1959 Northeast Pacific Street, Box 356420, Seattle, Washington 98195-6420, USA.
Jennifer A Brody1] Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Suite 1360, Seattle, Washington 98101, USA [2] Department of Medicine, University of Washington, 1959 Northeast Pacific Street, Box 356420, Seattle, Washington 98195-6420, USA.
Susan R Heckbert1] Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Suite 1360, Seattle, Washington 98101, USA [2] Department of Epidemiology, University of Washington, 1959 Northeast Pacific Street, Box 357236, Seattle, Washington 98195-7236, USA [3] Group Health Research Institute, Group Health Cooperative, 1730 Minor Avenue, Suite 1600, Seattle, Washington 98101-1448, USA.
Kenneth Rice1] Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Suite 1360, Seattle, Washington 98101, USA [2] Department of Biostatistics, University of Washington, 1959 Northeast Pacific Street, Box 357232, Seattle, Washington 98195-7323, USA.
Bruce M Psaty1] Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Suite 1360, Seattle, Washington 98101, USA [2] Department of Medicine, University of Washington, 1959 Northeast Pacific Street, Box 356420, Seattle, Washington 98195-6420, USA [3] Department of Epidemiology, University of Washington, 1959 Northeast Pacific Street, Box 357236, Seattle, Washington 98195-7236, USA [4] Group Health Research Institute, Group Health Cooperative, 1730 Minor Avenue, Suite 1600, Seattle, Washington 98101-1448, USA.
Funding
Pharmacoepidemiology and Pharmacogenetics of Statin AER01HL078888 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2015
$4.5MCardiovascular Safety of Combination Therapies for Type 2 Diabetes MellitusK08HL116640 · NHLBI · UNIVERSITY OF WASHINGTON · PI FLOYD, JAMES S · 2013 to 2017
$706kNHLBI NIH HHS K08 HL116640NHLBI NIH HHS R01 HL078888
Abstract
PubMed holds no abstract for this paper.
Indexed as
AmidinotransferasesGene Expression RegulationHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMuscular DiseasesQuantitative Trait LociSimvastatinAmidinotransferasesHydroxymethylglutaryl-CoA Reductase InhibitorsSimvastatin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.