ArticleNatural product communications2014
Bioactive secondary metabolites from acid mine waste extremophiles.
Article in Natural product communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- The Cytotoxic Properties of Extreme Fungi's Bioactive Components-An Updated Metabolic and Omics Overview.Life (Basel, Switzerland) · 2023Review
- Mining of novel secondary metabolite biosynthetic gene clusters from acid mine drainage.Scientific data · 2022Article
- Review
- Cryptic Biosynthesis of the Berkeleypenostatins from Coculture of ExtremophilicJournal of natural products · 2021Article
- Peculiarities of meroterpenoids and their bioproduction.Applied microbiology and biotechnology · 2021Review
- Antibiotics from Extremophilic Micromycetes.Russian journal of bioorganic chemistry · 2020Article
- An anti-HBV anthraquinone from aciduric fungus Penicillium sp. OUCMDZ-4736 under low pH stress.Extremophiles : life under extreme conditions · 2018Article
- The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture.Journal of natural products · 2017Article
- Azaphilones from an Acid Mine Extremophile Strain of a Pleurostomophora sp.Journal of natural products · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The extremophilic microbes of the Berkeley Pit Lake are a valuable source of new and interesting secondary metabolites. It is of particular interest that these acidophilic microbes produce small molecule inhibitors of pathways associated with low pH and high Eh. These same small molecules also inhibit molecular pathways induced by reactive oxygen species (ROS) and inflammation in mammalian cells. Low pH is a hallmark of inflammation and high Eh is one of ROS, so the suitability of this collection as a source of bioactive metabolites is actually quite biorational. Compound isolation was guided by inhibition of caspase-1 and matrix metalloproteinase-3, and active compounds were sent to the National Cancer Institute-Developmental Therapeutics Program and Memorial Sloan Kettering Cancer center for evaluation as either antiproliferative or cytotoxic agents.
Indexed as
Identifiers
25230522PMC5156321W2412230498What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.