ArticleEnvironmental health perspectives2014
Asthma in inner-city children at 5-11 years of age and prenatal exposure to phthalates: the Columbia Center for Children's Environmental Health Cohort.
Article in Environmental health perspectives, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.
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Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- Maternal Phthalate Exposure and Allergic Diseases in Children: A Meta-Analysis and Network Toxicology.International journal of molecular sciences · 2025Pooled it
- Phthalate Exposures and Placental Health in Animal Models and Humans: A Systematic Review.Toxicological sciences : an official journal of the Society of Toxicology · 2022Pooled it
- Operational definitions of paediatric asthma used in epidemiological studies: A systematic review.Journal of global health · 2021Pooled it
- Lowering Urinary Phthalate Metabolite Concentrations among Children by Reducing Contaminated Dust in Housing Units: A Randomized Controlled Trial and Observational Study.Environmental science & technology · 2020Trial
- Determination of the half-life of di(2-ethylhexyl) phthalate (DEHP) in a preterm neonate using blood transfusion as the source of intravenous exposure.Current research in toxicology · 2026Article
- Association of prenatal exposure to phthalates with risks of asthma, wheeze, and allergic diseases during childhood: a systematic review and meta-analysis.Journal of environmental health science & engineering · 2025Article
- Phthalates and bisphenols early-life exposure, and childhood allergic conditions: a pooled analysis of cohort studies.Journal of exposure science & environmental epidemiology · 2025Article
- Personal care product use and risk of adult-onset asthma: Prospective cohort analyses of U.S. Women from the Sister Study.Environment international · 2025Article
- A Machine Learning-Based Clustering Analysis to Explore Bisphenol A and Phthalate Exposure from Medical Devices in Infants with Congenital Heart Defects.Environmental health perspectives · 2025Article
- The association between environmental endocrine-disrupting chemicals and allergic disorders in children: A comprehensive systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Review
- Associations of environmental chemical exposures measured in personal silicone wristbands with sociodemographic factors, COVID-19 restrictions, and child respiratory health.Environmental research · 2024Article
- Urinary biomarkers of environmental exposures and asthma morbidity in a school inner city asthma study.International journal of hygiene and environmental health · 2024Article
- Associations of prenatal exposure to phthalates and their mixture with lung function in Mexican children.Journal of hazardous materials · 2024Article
- Recent Insights into the Environmental Determinants of Childhood Asthma.Current allergy and asthma reports · 2024Review
- Association Between Urinary Phthalate Metabolites and Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study.International journal of chronic obstructive pulmonary disease · 2024Article
- Phthalate exposure in the neonatal intensive care unit is associated with development of bronchopulmonary dysplasia.Environment international · 2023Article
- A cross sectional pilot study to assess the role of phthalates on respiratory morbidity among patients with chronic obstructive pulmonary disease.Environmental research · 2023Article
- A study on the association of placental and maternal urinary phthalate metabolites.Journal of exposure science & environmental epidemiology · 2023Article
- Environmental Health Knowledge Does Not Necessarily Translate to Action in Youth.International journal of environmental research and public health · 2023Article
- Mycotoxins fromMycology · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundStudies suggest that phthalate exposures may adversely affect child respiratory health.
objectivesWe evaluated associations between asthma diagnosed in children between 5 and 11 years of age and prenatal exposures to butylbenzyl phthalate (BBzP), di-n-butyl phthalate (DnBP), di(2-ethylhexyl) phthalate (DEHP), and diethyl phthalate (DEP).
methodsPhthalate metabolites were measured in spot urine collected from 300 pregnant inner-city women. Children were examined by an allergist or pulmonologist based on the first parental report of wheeze, other respiratory symptoms, and/or use of asthma rescue/controller medication in the preceding 12 months on repeat follow-up questionnaires. Standardized diagnostic criteria were used to classify these children as either having or not having current asthma at the time of the physician examination. Children without any report of wheeze or the other asthma-like symptoms were classified as nonasthmatics at the time of the last negative questionnaire. Modified Poisson regression analyses were used to estimate relative risks (RR) controlling for specific gravity and potential confounders.
resultsOf 300 children, 154 (51%) were examined by a physician because of reports of wheeze, other asthma-like symptoms, and/or medication use; 94 were diagnosed with current asthma and 60 without current asthma. The remaining 146 children were classified as nonasthmatic. Compared with levels in nonasthmatics, prenatal metabolites of BBzP and DnBP were associated with a history of asthma-like symptoms (p < 0.05) and with the diagnosis of current asthma: RR = 1.17 (95% CI: 1.01, 1.35) and RR = 1.25 (95% CI: 1.04, 1.51) per natural log-unit increase, respectively. Risk of current asthma was > 70% higher among children with maternal prenatal BBzP and DnBP metabolite concentrations in the third versus the first tertile.
conclusionPrenatal exposure to BBzP and DnBP may increase the risk of asthma among inner-city children. However, because this is the first such finding, results require replication.
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