ArticlePloS one2014
A genome-wide study of modern-day Tuscans: revisiting Herodotus's theory on the origin of the Etruscans.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Through 40,000 years of human presence in Southern Europe: the Italian case study.Human genetics · 2021Review
- The mitogenome portrait of Umbria in Central Italy as depicted by contemporary inhabitants and pre-Roman remains.Scientific reports · 2020Article
- A genome-wide association study of tramadol metabolism from post-mortem samples.The pharmacogenomics journal · 2020Article
- Ancestry patterns inferred from massive RNA-seq data.RNA (New York, N.Y.) · 2019Article
- Biogeographical origin and timing of the founder ichthyosis TGM1 c.1187G > A mutation in an isolated Ecuadorian population.Scientific reports · 2019Article
- A 2-transcript host cell signature distinguishes viral from bacterial diarrhea and it is influenced by the severity of symptoms.Scientific reports · 2018Article
- Mitochondrial DNA variants of Podolian cattle breeds testify for a dual maternal origin.PloS one · 2018Article
- Whole Exome Sequencing reveals new candidate genes in host genomic susceptibility to Respiratory Syncytial Virus Disease.Scientific reports · 2017Article
- Phylogeographic and genome-wide investigations of Vietnam ethnic groups reveal signatures of complex historical demographic movements.Scientific reports · 2017Article
- The time and place of European admixture in Ashkenazi Jewish history.PLoS genetics · 2017Article
- Genomic continuity of Argentinean Mennonites.Scientific reports · 2016Article
- The Italian genome reflects the history of Europe and the Mediterranean basin.European journal of human genetics : EJHG · 2016Article
- Mapping the genomic mosaic of two 'Afro-Bolivians' from the isolated Yungas valleys.BMC genomics · 2016Article
- Mitogenomes from The 1000 Genome Project reveal new Near Eastern features in present-day Tuscans.PloS one · 2015Article
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5 authors.
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Abstract
backgroundThe origin of the Etruscan civilization (Etruria, Central Italy) is a long-standing subject of debate among scholars from different disciplines. The bulk of the information has been reconstructed from ancient texts and archaeological findings and, in the last few years, through the analysis of uniparental genetic markers.
methodsBy meta-analyzing genome-wide data from The 1000 Genomes Project and the literature, we were able to compare the genomic patterns (>540,000 SNPs) of present day Tuscans (N = 98) with other population groups from the main hypothetical source populations, namely, Europe and the Middle East.
resultsAdmixture analysis indicates the presence of 25-34% of Middle Eastern component in modern Tuscans. Different analyses have been carried out using identity-by-state (IBS) values and genetic distances point to Eastern Anatolia/Southern Caucasus as the most likely geographic origin of the main Middle Eastern genetic component observed in the genome of modern Tuscans.
conclusionsThe data indicate that the admixture event between local Tuscans and Middle Easterners could have occurred in Central Italy about 2,600-3,100 years ago (y.a.). On the whole, the results validate the theory of the ancient historian Herodotus on the origin of Etruscans.
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