ArticleMolecules (Basel, Switzerland)2014
Anti-inflammatory and analgesic effects of the marine-derived compound comaparvin isolated from the crinoid Comanthus bennetti.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Pooled it
- Fatty Acids of Echinoderms: Diversity, Current Applications and Future Opportunities.Marine drugs · 2022Review
- Briarenols I-K, New Anti-inflammatory 8,17-Epoxybriaranes from the OctocoralMolecules (Basel, Switzerland) · 2020Article
- Different Macrophage Type Triggering as Target of the Action of Biologically Active Substances from Marine Invertebrates.Marine drugs · 2020Review
- Fragilides U-W: New 11,20-Epoxybriaranes from the Sea Whip Gorgonian CoralMarine drugs · 2019Article
- New 8-Hydroxybriaranes from the Gorgonian CoralMarine drugs · 2019Article
- New Furanocembranoids fromMarine drugs · 2019Article
- Capillasterin A, a Novel Pyrano[2,3-f]chromene from the Australian CrinoidMarine drugs · 2019Article
- Fragilides K and L, New Briaranes from the Gorgonian CoralMolecules (Basel, Switzerland) · 2018Article
- Anti-Inflammatory and Antinociceptive Effects of Ethyl Acetate Fraction of an Edible Red Macroalgae Sarcodia ceylanica.International journal of molecular sciences · 2017Article
- Coral-Derived Natural Marine Compound GB9 Impairs Vascular Development in Zebrafish.International journal of molecular sciences · 2017Article
- Anti-inflammatory and burn injury wound healing properties of the shell of Haliotis diversicolor.BMC complementary and alternative medicine · 2016Article
- New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris.Marine drugs · 2015Article
- Anti-Inflammatory and Analgesic Effects of the Marine-Derived Compound Excavatolide B Isolated from the Culture-Type Formosan Gorgonian Briareum excavatum.Marine drugs · 2015Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, no study has been conducted to explore the bioactivity of the crinoid Comanthus bennetti. Here we report the anti-inflammatory properties of comaparvin (5,8-dihydroxy-10-methoxy-2-propylbenzo[h]chromen-4-one) based on in vivo experiments. Our preliminary screening for anti-inflammatory activity revealed that the crude extract of Comanthus bennetti significantly inhibited the expression of pro-inflammatory proteins in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophage cells. Comaparvin isolated from crinoids significantly decreased the expression of inducible nitric oxide synthase (iNOS) protein and mRNA in LPS-stimulated macrophage cells. Moreover, our results showed that post-treatment with comaparvin significantly inhibited mechanical allodynia, thermal hyperalgesia and weight-bearing deficits in rats with carrageenan-induced inflammation. Comaparvin also attenuated leukocyte infiltration and iNOS protein expression in carrageenan-induced inflamed paws. These results suggest that comaparvin is a potential anti-inflammatory therapeutic agent against inflammatory pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.