ArticleThe Laryngoscope2014
Polymorphous low-grade adenocarcinoma: a case series and determination of recurrence.
Article in The Laryngoscope, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Cribriform Adenocarcinoma of the Nasal Cavity Harboring a NovelCase reports in pathology · 2025Article
- Clinicopathological Features of 26 Intraoral Polymorphous Adenocarcinomas from a Single Brazilian Institution.Head and neck pathology · 2024Article
- Stereotactic radiosurgery for recurrent skull base polymorphous adenocarcinoma invading the cavernous sinus: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- Role of elective neck dissection and adjuvant radiation therapy in patients with polymorphous adenocarcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Salivary gland carcinoma in Denmark: a national update and follow-up on incidence, histology, and outcome.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Polymorphous Adenocarcinoma.Surgical pathology clinics · 2021Review
- Histologic Classification and Molecular Signature of Polymorphous Adenocarcinoma (PAC) and Cribriform Adenocarcinoma of Salivary Gland (CASG): An International Interobserver Study.The American journal of surgical pathology · 2020Article
- Historical Evolution of the Polymorphous Adenocarcinoma.Head and neck pathology · 2019Review
- Polymorphous adenocarcinoma of salivary glands.Oral oncology · 2019Article
- Polymorphous adenocarcinoma of the salivary glands: reappraisal and update.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Review
- World Health Organization 4th edition of head and neck tumor classification: insight into the consequential modifications.Virchows Archiv : an international journal of pathology · 2018Article
- Synchronous Polymorphous Adenocarcinoma and Canalicular Adenoma on the Upper Lip: An Unusual Presentation and Immunohistochemical Analysis.Head and neck pathology · 2018Article
- What Is New in the World Health Organization 2017 Histopathology Classification?Current treatment options in oncology · 2017Article
- Predictors of Outcome in the Phenotypic Spectrum of Polymorphous Low-grade Adenocarcinoma (PLGA) and Cribriform Adenocarcinoma of Salivary Gland (CASG): A Retrospective Study of 69 Patients.The American journal of surgical pathology · 2016Article
- Polymorphous Low-Grade Adenocarcinoma of the Salivary Glands - A Review.Nigerian medical journal : journal of the Nigeria Medical AssociationReview
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7 authors.
Funding
Abstract
objectives/hypothesisInformation on polymorphous low-grade adenocarcinoma (PLGA) consists primarily of case reports and small institutional series with varying recurrence rates. In this report, we describe our institutional experience and conduct a review of the literature to assess the overall incidence of PLGA among oral salivary gland tumors and determine recurrence rates. STUDY
designA retrospective case series and literature-based review was performed.
methodsRetrospective case series at an academic tertiary referral center. Review of clinical records and pathological analysis of tissue specimens from 20 patients treated for PLGA from July 1, 1990 to July 1, 2011. A literature-based review on PLGA was also performed.
resultsTwenty patients (mean age, 54 years; eight males) with PLGA based on pathologic diagnosis were included. The most common initial presentation was an asymptomatic mass (45%), and the most frequent site was the palate (60%). Our literature review identified 54 case reports, eight case series, and 17 large series. In total, 456 cases of PLGA were identified, with an overall recurrence rate of 19%. Half of the recurrences occurred by 36 months; however, recurrences were reported up to 24 years after initial resection.
conclusionsPLGA arises from minor salivary glands and is characteristically slow growing and indolent. Although these tumors may be histologically low-grade, our review highlights the high rates of recurrence of these tumors as well as the ability to metastasize to local lymph nodes and distant organs. The mainstay of treatment should be wide surgical excision with long-term oncologic follow-up. LEVEL OF EVIDENCE: 4.
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