ArticlePloS one2014
Ectopic osteoid and bone formation by three calcium-phosphate ceramics in rats, rabbits and dogs.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- A ceramic microbridge microfluidic chip to study osteogenic differentiation of mesenchymal stem cells in bioactive ceramic immune microenvironment.Bioactive materials · 2025Article
- Calcium-to-phosphorus releasing ratio affects osteoinductivity and osteoconductivity of calcium phosphate bioceramics in bone tissue engineering.Biomedical engineering online · 2023Article
- Does low-intensity pulsed ultrasound accelerate phasic calcium phosphate ceramic-induced bone formation?Acta cirurgica brasileira · 2023Article
- Osteoregenerative efficacy of a novel synthetic, resorbable Ca/P/S-based bone graft substitute in intra- and peri-articular fractures: a brief medical image-based report.Journal of orthopaedic surgery and research · 2022Article
- The Relationship between Osteoinduction and Vascularization: Comparing the Ectopic Bone Formation of Five Different Calcium Phosphate Biomaterials.Materials (Basel, Switzerland) · 2022Article
- Proangiogenic Hypoxia-Mimicking Agents Attenuate Osteogenic Potential of Adipose Stem/Stromal Cells.Tissue engineering and regenerative medicine · 2020Article
- Controlled M1-to-M2 transition of aged macrophages by calcium phosphate coatings.Biomaterials · 2019Article
- A Col I and BCP ceramic bi-layer scaffold implant promotes regeneration in osteochondral defects.RSC advances · 2019Article
- Heterotopic bone formation in the musculus latissimus dorsi of sheep using β-tricalcium phosphate scaffolds: evaluation of different seeding techniques.Regenerative biomaterials · 2018Article
- Bone repair access of BoneCeramic™ in 5-mm defects: study on rat calvaria.Journal of applied oral science : revista FOB · 2018Article
- Design and characterization of calcium phosphate ceramic scaffolds for bone tissue engineering.Dental materials : official publication of the Academy of Dental Materials · 2016Review
- Angiogenesis in tissue-engineered nerves evaluated objectively using MICROFIL perfusion and micro-CT scanning.Neural regeneration research · 2016Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium phosphate ceramics with specific physicochemical properties have been shown to induce de novo bone formation upon ectopic implantation in a number of animal models. In this study we explored the influence of physicochemical properties as well as the animal species on material-induced ectopic bone formation. Three bioceramics were used for the study: phase-pure hydroxyapatite (HA) sintered at 1200°C and two biphasic calcium phosphate (BCP) ceramics, consisting of 60 wt.% HA and 40 wt.% TCP (β-Tricalcium phosphate), sintered at either 1100°C or 1200°C. 108 samples of each ceramic were intramuscularly implanted in dogs, rabbits, and rats for 6, 12, and 24 weeks respectively. Histological and histomorphometrical analyses illustrated that ectopic bone and/or osteoid tissue formation was most pronounced in BCP sintered at 1100°C and most limited in HA, independent of the animal model. Concerning the effect of animal species, ectopic bone formation reproducibly occurred in dogs, while in rabbits and rats, new tissue formation was mainly limited to osteoid. The results of this study confirmed that the incidence and the extent of material-induced bone formation are related to both the physicochemical properties of calcium phosphate ceramics and the animal model.
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