ArticlePloS one2014
Physical activity and cardiorespiratory fitness are beneficial for white matter in low-fit older adults.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Sedentary behavior, cognition, and brain health in older adults: a systematic review.Frontiers in aging neuroscience · 2025Pooled it
- A systematic review and meta-analysis of the effects of physical exercise on white matter integrity and cognitive function in older adults.GeroScience · 2024Pooled it
- Neuroscience meets behavior: A systematic literature review on magnetic resonance imaging of the brain combined with real-world digital phenotyping.Human brain mapping · 2024Pooled it
- Review articles (Meta-Analyses) effects of walking on cognitive function in individuals with mild cognitive impairment: a systematic review and meta-analysis.BMC geriatrics · 2023Pooled it
- Associations of cardiorespiratory fitness and exercise with brain white matter in healthy adults: A systematic review and meta-analysis.Brain imaging and behavior · 2022Pooled it
- Objectively Measured Sedentary Behavior and Physical Fitness in Adults: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- A systematic review of MRI studies examining the relationship between physical fitness and activity and the white matter of the ageing brain.NeuroImage · 2016Pooled it
- Changes in cardiovascular health and white matter integrity with aerobic exercise, cognitive and combined training in physically inactive healthy late-middle-aged adults: the "Projecte Moviment" randomized controlled trial.European journal of applied physiology · 2024Trial
- Change in Views of Aging, Physical Activity, and Physical Health Over 8 Weeks: Results From a Randomized Study.Journal of aging and physical activity · 2023Trial
- Sensor-measured sedentariness and physical activity are differentially related to fluid and crystallized abilities in aging.Psychology and aging · 2020Trial
- Improving fitness increases dentate gyrus/CA3 volume in the hippocampal head and enhances memory in young adults.Hippocampus · 2020Trial
- Relationship of regional brain β-amyloid to gait speed.Neurology · 2016Trial
- Moderate Physical Activity Mediates the Association between White Matter Lesion Volume and Memory Recall in Breast Cancer Survivors.PloS one · 2016Trial
- Review
- Article
- Cardiorespiratory fitness is differentially associated with motor cortex laterality in middle-aged and older adults.Scientific reports · 2026Article
- Associations of cardiorespiratory fitness with brain white matter microstructural integrity and white matter hyperintensity volume across the adult lifespan.GeroScience · 2026Article
- Exercise Delays Brain Ageing Through Muscle-Brain Crosstalk.Cell proliferation · 2025Review
- Pattern of change and predictors of cognitive function in older adults receiving allogeneic hematopoietic cell transplantation using the Montreal cognitive assessment.Journal of cancer survivorship : research and practice · 2025Article
- Optimizing treatment of cardiovascular risk factors in cerebral small vessel disease using genetics.Brain : a journal of neurology · 2025Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
Physical activity (PA) and cardiorespiratory fitness (CRF) are associated with better cognitive function in late life, but the neural correlates for these relationships are unclear. To study these correlates, we examined the association of both PA and CRF with measures of white matter (WM) integrity in 88 healthy low-fit adults (age 60-78). Using accelerometry, we objectively measured sedentary behavior, light PA, and moderate to vigorous PA (MV-PA) over a week. We showed that greater MV-PA was related to lower volume of WM lesions. The association between PA and WM microstructural integrity (measured with diffusion tensor imaging) was region-specific: light PA was related to temporal WM, while sedentary behavior was associated with lower integrity in the parahippocampal WM. Our findings highlight that engaging in PA of various intensity in parallel with avoiding sedentariness are important in maintaining WM health in older age, supporting public health recommendations that emphasize the importance of active lifestyle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.