ArticleKidney international2015
Urinary L-FABP predicts poor outcomes in critically ill patients with early acute kidney injury.
Article in Kidney international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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41 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Novel biomarkers for predicting successful liberation of renal replacement therapy for acute kidney injury: a systematic review.Critical care (London, England) · 2025Pooled it
- Urinary neutrophil gelatinase-associated lipocalin-guided risk assessment for major adverse kidney events after open-heart surgery.Biomarkers in medicine · 2018Trial
- Evaluation of FABP1 as a biomarker of diabetic kidney disease in children with type 1 diabetes.European journal of pediatrics · 2026Article
- Prognosis prediction by urinary liver-type fatty acid-binding protein in patients in the intensive care unit admitted from the emergency department: A single-center, historical cohort study.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026Article
- Urine Tubular Biomarkers Are Associated With Natriuresis in Patients With Acute Heart Failure.Journal of the American Heart Association · 2025Article
- Serum fibroblast growth factor 23 and kidney injury molecule-1 in the prediction of acute kidney injury in critically-ill patients.Renal failure · 2025Article
- Kidney Tubular Biomarkers Predict Risk of Death and Heart Failure Readmission in Acute Heart Failure.Journal of the American Heart Association · 2025Article
- Can Novel Biomarkers Effectively Predict Acute Kidney Injury in Liver or Kidney Transplant Recipients?International journal of molecular sciences · 2024Review
- Urinary L-FABP Assay in the Detection of Acute Kidney Injury following Haematopoietic Stem Cell Transplantation.Journal of personalized medicine · 2024Article
- Trajectory pattern of serially measured acute kidney injury biomarkers in critically ill patients: a prospective observational study.Annals of intensive care · 2024Article
- Urinary Epidermal Growth Factor Level as a Noninvasive Indicator of Tubular Repair in Patients with Acute Kidney Injury.Diagnostics (Basel, Switzerland) · 2024Article
- Urinary liver-type fatty acid-binding protein levels may be associated with the occurrence of acute kidney injury induced by trauma.Frontiers in medicine · 2024Article
- Urinary Liver-Type Fatty Acid Binding Protein, a Biomarker for Disease Progression, Dialysis and Overall Mortality in Chronic Kidney Disease.Journal of personalized medicine · 2023Article
- Increased numbers of pre-operative circulating monocytes predict risk of developing cardiac surgery-associated acute kidney injury in conditions requiring cardio pulmonary bypass.Clinical and experimental nephrology · 2023Article
- Prospective evaluation of novel biomarkers of acute kidney injury in dogs following cardiac surgery under cardiopulmonary bypass.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2022Article
- Assessment of Urinary Exosomal NHE3 as a Biomarker of Acute Kidney Injury.Diagnostics (Basel, Switzerland) · 2022Article
- In PICU acute kidney injury stage 3 or mortality is associated with early excretion of urinary renin.Pediatric research · 2022Article
- Urinary Activin A: A Novel Biomarker for Human Acute Kidney Injury.Diagnostics (Basel, Switzerland) · 2022Article
- Combining renal cell arrest and damage biomarkers to predict progressive AKI in patient with sepsis.BMC nephrology · 2021Article
- Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury.The Journal of pathology · 2021Article
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8 authors at 2 institutions in 1 country.
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Abstract
Biomarker studies for early detection of acute kidney injury (AKI) have been limited by nonselective testing and uncertainties in using small changes in serum creatinine as a reference standard. Here we examine the ability of urine L-type fatty acid-binding protein (L-FABP), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), and kidney injury molecule-1 (KIM-1) to predict injury progression, dialysis, or death within 7 days in critically ill adults with early AKI. Of 152 patients with known baseline creatinine examined, 36 experienced the composite outcome. Urine L-FABP demonstrated an area under the receiver-operating characteristic curve (AUC-ROC) of 0.79 (95% confidence interval 0.70-0.86), which improved to 0.82 (95% confidence interval 0.75-0.90) when added to the clinical model (AUC-ROC of 0.74). Urine NGAL, IL-18, and KIM-1 had AUC-ROCs of 0.65, 0.64, and 0.62, respectively, but did not significantly improve discrimination of the clinical model. The category-free net reclassification index improved with urine L-FABP (total net reclassification index for nonevents 31.0%) and urine NGAL (total net reclassification index for events 33.3%). However, only urine L-FABP significantly improved the integrated discrimination index. Thus, modest early changes in serum creatinine can help target biomarker measurement for determining prognosis with urine L-FABP, providing independent and additive prognostic information when combined with clinical predictors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.