Evidence map›Paper›PMID 25229186›Full record

ReviewFree radical biology & medicine2014

Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility.

Katsuhiko Ono, Takaaki Akaike, Tomohiro Sawa, Yoshito Kumagai, David A Wink, Dean J Tantillo, Adrian J Hobbs, Peter Nagy, Ming Xian, Joseph Lin and 1 more

Abstract readReview
In one paragraph

Review in Free radical biology & medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

162 citing papers in PubMed.

  1. Review
  2. Unravelling the Therapeutic Potential of Cysteine for Cardiovascular Health.International journal of molecular sciences · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Intracellular Crosstalk of the Gasotransmitter Trio (NO, CO, HInternational journal of molecular sciences · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. A Dinuclear Iron(II) Persulfide Complex Reacts with OJournal of the American Chemical Society · 2026
    Article
  13. Article
  14. Article
  15. Review
  16. Fueling Death: The Metabolic Control of Ferroptosis.Advances in experimental medicine and biology · 2026
    Review
  17. Article
  18. Article
  19. Article
  20. Article

102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Katsuhiko OnoDepartment of Chemistry, Sonoma State University, Rohnert Park, CA 94928, USA.
Takaaki AkaikeDepartment of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Tomohiro SawaDepartment of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Yoshito KumagaiDoctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
David A WinkTumor Biology Section, Radiation Biology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
Dean J TantilloDepartment of Chemistry, University of California, Davis, 1 Shields Avenue, Davis, CA 95616, USA.
Adrian J HobbsWilliam Harvey Research Institute, Bart & London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Peter NagyDepartment of Molecular Immunology and Toxicology, National Institute of Oncology, Budapest, Hungary.
Ming XianDepartment of Chemistry, Washington State University, Pullman, WA 99164, USA.
Joseph LinDepartment of Biology, Sonoma State University, Rohnert Park, CA 94928, USA.
Jon M FukutoDepartment of Chemistry, Sonoma State University, Rohnert Park, CA 94928, USA. Electronic address: fukuto@sonoma.edu.

Funding

Novel Sulfide Releasing Agents for Ischemic InjuryR01HL116571 · NHLBI · WASHINGTON STATE UNIVERSITY · PI LEFER, DAVID JOSEPH, XIAN, MING · 2014 to 2017
$1.8M
Biological Chemistry and Pharmacology of Nitroxyl (HNO)R15HL106598 · NHLBI · SONOMA STATE UNIVERSITY · PI FUKUTO, JON · 2012 to 2012
$357k
NHLBI NIH HHS HL106598NHLBI NIH HHS R01 HL116571NHLBI NIH HHS R01HL116571NHLBI NIH HHS R15 HL106598
6 · The paper itself

Abstract

Hydrogen sulfide (H2S) is an endogenously generated and putative signaling/effector molecule. Despite its numerous reported functions, the chemistry by which it elicits its functions is not understood. Moreover, recent studies allude to the existence of other sulfur species besides H2S that may play critical physiological roles. Herein, the basic chemical biology of H2S as well as other related or derived species is discussed and reviewed. This review particularly focuses on the per- and polysulfides which are likely in equilibrium with free H2S and which may be important biological effectors themselves.

Indexed as

AnimalsBiosynthetic PathwaysCell CommunicationDisulfidesHumansHydrogen SulfideOxidation-ReductionSignal TransductionDisulfidesHydrogen SulfideHydrogen sulfidePersulfidesPolysulfidesThiol redoxThiols

Identifiers

PMID25229186
PMCPMC4258476

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.