ArticleJournal of diabetes and metabolic disorders2014
Lean mass is the strongest predictor of bone mineral content in type-2 diabetes and normal individuals: an eastern India perspective.
Article in Journal of diabetes and metabolic disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Glucagon-Like Peptide-1 Receptor Agonists in Post-bariatric Surgery Patients: A Systematic Review and Meta-analysis.Obesity surgery · 2024Pooled it
- Lower levels of vitamin D are associated with SARS-CoV-2 infection and mortality in the Indian population: An observational study.International immunopharmacology · 2020Observational
- Relationships between bone mineral density, body composition, and isokinetic strength in postmenopausal women.Bone reports · 2020Review
- Occurrence & predictors of osteoporosis & impact of body composition alterations on bone mineral health in asymptomatic pre-menopausal women with HIV infection.The Indian journal of medical research · 2018Article
- Association between Anthropometric Indices, Body Composition and Bone Parameters in Thai Female Adolescents.Indian journal of pediatrics · 2017Article
- Lean Mass and Disease Activity are the Best Predictors of Bone Mineral Loss in the Premenopausal Women with Rheumatoid Arthritis.Indian journal of endocrinology and metabolismArticle
- Systematic Review on Vitamin D Level in Apparently Healthy Indian Population and Analysis of Its Associated Factors.Indian journal of endocrinology and metabolismReview
- Vitamin D, Thyroid Autoimmunity and Cancer: An Interplay of Different Factors.Indian journal of endocrinology and metabolismReview
- Severity and pattern of bone mineral loss in endocrine causes of osteoporosis as compared to age-related bone mineral loss.Journal of postgraduate medicineArticle
- Role of Aromatase Inhibitors in Managing Hypogonadism in Adult Males Related to Obesity and Aging: A Systematic Review and Meta-Analysis.Indian journal of endocrinology and metabolismReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImpact of body fat distribution on bone mineral content (BMC) and density (BMD) at different sites has not been studied in type-2 diabetes (T2DM). This study aimed to compare BMC and BMD in normal (BMI < 25 kg/m(2)) and increased BMI (BMI ≥ 25 kg/m(2)) T2DM patients with age and BMI matched normal controls, and evaluate the impact of lean mass and body fat distribution parameters on them.
methodsSeventy-six T2DM patients and 56 normal controls underwent anthropometric assessment, blood sampling and estimation of BMC, BMD, body fat and lean mass distribution by dual energy X-ray absorptiometry (DXA).
resultsIncreased BMI individuals (n = 63) had significantly higher BMD, BMC, fat mass and significantly lower 25-hydroxy-vitamin-D (25OHD), as compared to normal BMI individuals (n = 69). Lean mass had stronger positive correlation with BMC and BMD, compared to fat mass. BMI, sagittal abdominal diameter (SAD) and Android/Gynoid (A/G) ratio had positive correlation with BMC and BMD. Percent body fat had negative correlation with BMC and BMD. T2DM patients had higher central obesity (A/G ratio). WC was the best predictor of A/G ratio. Regression analysis revealed lean mass to be the strongest predictor of BMC after adjusting for age, sex, BMI and 25OHD, in normal individuals and patients with diabetes, followed by fat mass. BMD right femur, BMC, lean mass and A/G ratios were significantly higher in males (n = 74). Fat mass and percent body fat were significantly higher in females (n = 58). Fat mass was the best predictor of BMC in males where as lean mass was the best predictor of BMC in females.
conclusionIncreased BMI and T2DM are associated with increased BMC and BMD at different sites, with lean mass having the strongest impact on BMC in normal individuals and patients with diabetes. Males have higher BMC and BMD as compared to females, likely due to a greater lean mass, A/G ratio, along with lesser fat mass and percent body fat.
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