ArticleAllergy, asthma & immunology research2014
Increased Th2-like Invariant Natural Killer T cells in Peripheral Blood From Patients With Asthma.
Article in Allergy, asthma & immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Natural killer T-cells in asthma pathogenesis and treatment: old problems and future perspectives.ERJ open research · 2025Review
- Decoding innate lymphoid cells and innate-like lymphocytes in asthma: pathways to mechanisms and therapies.Journal of biomedical science · 2025Review
- Natural killer T cells in allergic asthma: implications for the development of novel immunotherapeutical strategies.Frontiers in immunology · 2024Review
- Article
- Characteristics of the oropharyngeal microbiota among infants with pneumonia and their effects on immune response and subsequent respiratory morbidity.European journal of pediatrics · 2023Article
- T-cell responses in asthma exacerbations.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Review
- New Insights into Asthma Inflammation: Focus on iNKT, MAIT, and γδT Cells.Clinical reviews in allergy & immunology · 2020Review
- Specific Polyunsaturated Fatty Acids Can ModulateFrontiers in immunology · 2020Article
- The role of invariant T cells in inflammation of the skin and airways.Seminars in immunopathology · 2019Review
- Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma.The Journal of allergy and clinical immunology · 2018Article
- Development of Asthma in Inner-City Children: Possible Roles of MAIT Cells and Variation in the Home Environment.Journal of immunology (Baltimore, Md. : 1950) · 2018Observational
- Invariant Natural Killer T and Mucosal-Associated Invariant T Cells in Asthmatic Patients.Frontiers in immunology · 2018Review
- Role of CD1d- and MR1-Restricted T Cells in Asthma.Frontiers in immunology · 2018Review
- Flagellin Modulates the Function of Invariant NKT Cells From Patients With Asthma via Dendritic Cells.Allergy, asthma & immunology research · 2016Article
- β-Catenin is required for the differentiation of iNKT2 and iNKT17 cells that augment IL-25-dependent lung inflammation.BMC immunology · 2015Article
- Natural killer cells in the development of asthma.Current allergy and asthma reports · 2015Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeInvariant natural killer T (iNKT) cells might play an important role in asthma pathogenesis in humans. Our previous study found no difference in the number of blood iNKT cells between asthma patients and controls. However, few studies have examined the function of blood iNKT cells in human asthma.
methodsTwenty asthma patients and eight controls were included in this study. Blood iNKT cells were identified using double staining with anti-Vα24 and anti-Vβ11 monoclonal antibodies (mAbs) or with 6B11 and anti-Vβ11 mAbs. Intracellular IL-4, IL-10, and IFN-γ cytokines were stained in blood iNKT cells using their respective mAbs and isotypes. In addition, their relationships with clinical parameters were analyzed.
resultsThe number of Vα24+Vβ11+ iNKT cells or 6B11+Vβ11+ iNKT cells did not differ between asthma patients and controls. However, among Vα24+Vβ11+iNKT cells, the proportion of IL-4+iNKT cells was increased in asthma patients compared to controls (7.0±3.0% vs 0.5%±0.4%, P<0.05). There were no differences in the proportions of IL-10+or IFN-γ+iNKT cells between the groups. The proportion of IL-4+ cells among 6B11+Vβ11+iNKT cells inversely correlated with FEV1, expressed as a percentage predicted value in asthma patients (Rs=-0.64, P<0.05, n=19).
conclusionsBlood iNKT cells are thought to be Th2-like, and IL-4-producing iNKT cells may be associated with lung function in human asthma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.