ReviewAllergy, asthma & immunology research2014
Small airways dysfunction in asthma: evaluation and management to improve asthma control.
Review in Allergy, asthma & immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Comparison of extrafine and non-extrafine inhaled corticosteroids/long-acting β2-agonists as maintenance and reliever therapy in asthma: a randomized open-label crossover trial.The Korean journal of internal medicine · 2025Trial
- Long-Acting Muscarinic Antagonists for the Treatment of Difficult-to-Treat and Severe Asthma: A Narrative Review Focusing on Inflammation from Bench to Bedside.Journal of inflammation research · 2026Review
- Early benefit of mepolizumab on small airways in severe asthma: insights from the IMPOSE study.ERJ open research · 2025Article
- Small Airways Disease as a Novel Target for Mepolizumab in Asthma-The SASAM Prospective Real-Life Study.Journal of clinical medicine · 2025Article
- Detecting Peripheral Airway Response in Exercise-Induced Bronchoconstriction: The Role of Impulse Oscillometry.Respiratory care · 2025Article
- Aerodynamic Simulation of Small Airway Resistance: A New Imaging Biomarker for Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2024Article
- Small airway dysfunction measured by impulse oscillometry is associated with exacerbations and poor symptom control in patients with asthma treated in a tertiary hospital subspecialist airways disease clinic.Frontiers in allergy · 2024Article
- Small airways in asthma: Pathophysiology, identification and management.Chinese medical journal pulmonary and critical care medicine · 2023Review
- Fixed-dose combination fluticasone/formoterol for asthma treatment in a real-world setting: meta-analysis of exacerbation rates and asthma control.European clinical respiratory journal · 2023Review
- Peripheral airways involvement in children with asthma exacerbation.The clinical respiratory journal · 2022Article
- Small Airway Disease in Pediatric Asthma: the Who, What, When, Where, Why, and How to Remediate. A Review and Commentary.Clinical reviews in allergy & immunology · 2022Review
- The Value of Fractional Exhaled Nitric Oxide and Impulse Oscillometric and Spirometric Parameters for Predicting Bronchial Hyperresponsiveness in Adults with Chronic Cough.Journal of asthma and allergy · 2021Article
- Efficacy and Safety of a Pressurized Metered-Dose Inhaler in Older Asthmatics: Comparison to a Dry Powder Inhaler in a 12-Week Randomized Trial.Allergy, asthma & immunology research · 2020Article
- Article
- Small Airways Dysfunction and Bronchial Hyper-Responsiveness in Cough Variant Asthma.International journal of general medicine · 2020Article
- Concurrent absorption and secretion of airway surface liquids and bicarbonate secretion in human bronchioles.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Is there room for further innovation in inhaled therapy for airways disease?Breathe (Sheffield, England) · 2018Review
- [Comparison of functional parameters of small airways between patients with typical asthma and cough-variant asthma].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Asthma-Related Outcomes in Patients Initiating Extrafine Ciclesonide or Fine-Particle Inhaled Corticosteroids.Allergy, asthma & immunology research · 2017Article
- Recognition of Small Airways Obstruction in Asthma and COPD - The Road Less Travelled.Journal of clinical and diagnostic research : JCDR · 2017Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The small airways have been neglected for many years, but interest in the topic has been rekindled with recent advances in measurement techniques to assess this region and also the ability to deliver therapeutics to the distal airways. Current levels of disease control in asthmatic patients remain poor and there are several contributory factors including; poor treatment compliance, heterogeneity of asthma phenotypes and associated comorbidities. However, the proposition that we may not be targeting all the inflammation that is present throughout the whole respiratory tree may also be an important factor. Indeed decades ago, pathologists and physiologists clearly identified the importance of small airways dysfunction in asthmatic patients. With improved inhaler technology to deliver drug to target the whole respiratory tree and more sensitive measures to assess the distal airways, we should certainly give greater consideration to treating the small airway region when seeing our asthmatic patients in clinic. The aim of this review is to address the relevance of small airways dysfunction in the daily clinical management of patients with asthma. In particular the role of small particle aerosols in the management of patients with asthma will be explored.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.