Trial reportGut and liver2014
The need for second-look endoscopy to prevent delayed bleeding after endoscopic submucosal dissection for gastric neoplasms: a prospective randomized trial.
Trial report in Gut and liver, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03070665 (Increasing Blood Pressure During Gastric ESD May Control the Risk of Postoperative Bleeding), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Increasing Blood Pressure During Gastric ESD May Control the Risk of Postoperative Bleeding: a Prospective Randomized Trial
Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Second-look endoscopy does not reduce delayed bleeding after endoscopic papillectomy: a multicenter propensity score-matched analysis.Therapeutic advances in gastroenterology · 2026Article
- Artificial intelligence-assisted diagnosis of early gastric cancer: present practice and future prospects.Annals of medicine · 2025Review
- Efficacy of alternate mucosa-submucosa clip closure in preventing postoperative adverse events for patients with gastric mucosal lesions after endoscopic submucosal dissection: a multicenter retrospective study.Therapeutic advances in gastroenterology · 2025Article
- Role of second look endoscopy in endoscopic submucosal dissection and peptic ulcer bleeding: Meta-analysis of randomized controlled trials.World journal of gastrointestinal endoscopy · 2024Article
- Complications of endoscopic resection in the upper gastrointestinal tract.Clinical endoscopy · 2023Review
- Complete omission of second-look endoscopy after gastric endoscopic submucosal dissection in real-world practice.Medicine · 2022Article
- Does second-look endoscopy reduce the bleeding after gastric endoscopic submucosal dissection for patients receiving antithrombotic therapy?BMC cancer · 2021Article
- Optimal procedure-related hospitalization using clinical pathway protocols following gastric endoscopic submucosal dissection.Surgical endoscopy · 2021Article
- Current evidence and issues of endoscopic submucosal dissection for gastric neoplasms during antithrombotic therapy.Clinical journal of gastroenterology · 2020Review
- Risk factors for delayed bleeding by onset time after endoscopic submucosal dissection for gastric neoplasm.Scientific reports · 2019Article
- Efficacy of second-look endoscopy in preventing delayed bleeding after endoscopic submucosal dissection of early gastric cancer.Experimental and therapeutic medicine · 2018Article
- Article
- Is the Reinitiation of Antiplatelet Agents Safe at 1 Week after Gastric Endoscopic Submucosal Dissection? Assessment of Bleeding Risk Using the Forrest Classification.Gut and liver · 2017Article
- Endoscopic submucosal dissection of gastric tumors: A systematic review and meta-analysis.World journal of gastrointestinal endoscopy · 2016Article
- Bleeding after endoscopic submucosal dissection: Risk factors and preventive methods.World journal of gastroenterology · 2016Review
- Second-Look Endoscopy after Endoscopic Submucosal Dissection: Can We Obtain Valuable Information?Clinical endoscopy · 2016Article
- Second-look endoscopy and factors associated with delayed bleeding after endoscopic submucosal dissection.World journal of gastrointestinal endoscopy · 2016Review
- Second-look endoscopy with prophylactic hemostasis is still effective after endoscopic submucosal dissection for gastric neoplasm.World journal of gastroenterology · 2015Article
- Second-Look Endoscopy After ESD: Can We Finally See the Forrest from the Trees?Digestive diseases and sciences · 2015Article
- Second-look endoscopy after gastric endoscopic submucosal dissection for reducing delayed postoperative bleeding.Gut and liver · 2015Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsMany authors recommend performing a second-look endoscopy (SLE) to reduce the frequency of delayed bleeding after endoscopic submucosal dissection (ESD) for gastric neoplasms, but these recommendations have been made despite a lack of reliable evidence supporting the effectiveness of SLE.
methodsFrom January 2012 to May 2013, we investigated 441 gastric neoplasms treated by ESD to assess the risk factors for delayed bleeding. Delayed bleeding occurred in four of these lesions within 1 postoperation day. Therefore, we enrolled the patients with the remaining 437 lesions to determine the utility of SLE performed on the morning of postoperative day 2. All lesions were randomly assigned to SLE (220 lesions) groups or non-SLE (217 lesions) groups.
resultsDelayed bleeding occurred in 18 lesions (4.1%). A large tumor size (>20 mm) was the only independent risk factor for delayed bleeding (p=0.007). The chance of delayed bleeding was not significantly different between the patients receiving a SLE (eight cases) and those patients not receiving a SLE (six cases, p=0.787). Furthermore, SLE for lesions with a large tumor size did not significantly decrease delayed bleeding (p=0.670).
conclusionsSLE had little or no influence on the prevention of delayed bleeding, irrespective of the risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.