ReviewGut and liver2014
Recent advances in the concept and pathogenesis of IgG4-related disease in the hepato-bilio-pancreatic system.
Review in Gut and liver, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- IgG4-related disease - focus on digestive system involvement.Frontiers in immunology · 2025Review
- [Advances in gut microbiomes and immunology of IgG4-related hepatobiliary and pancreatic diseases].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Review
- Clinical Characteristics and Potential Mechanisms in Patients with Abnormal Liver Function Indices and Elevated Serum IgG4.Canadian journal of gastroenterology & hepatology · 2022Article
- IgG4-related Disease Manifesting as Gastroduodenal Ulcer Diagnosed by an Endoscopic Biopsy.Internal medicine (Tokyo, Japan) · 2020Article
- Steroid Therapy and Steroid Response in Autoimmune Pancreatitis.International journal of molecular sciences · 2019Review
- Common features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas.World journal of gastroenterology · 2019Review
- Ectopic relapse of IgG4-related disease presenting as IgG4-related sclerosing cholecystitis: A case report and review of literature.Medicine · 2018Article
- Possible relationship between fibrosis of IgG4-related thymitis and the profibrotic cytokines, transforming growth factor beta 1, interleukin 1 beta and interferon gamma: a case report.Diagnostic pathology · 2018Article
- Systematic Investigation of Scutellariae Barbatae Herba for Treating Hepatocellular Carcinoma Based on Network Pharmacology.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Article
- Transpapillary biliary stenting is a risk factor for pancreatic stones in patients with autoimmune pancreatitis.Endoscopy international open · 2016Article
- Progenitor cell niches in the human pancreatic duct system and associated pancreatic duct glands: an anatomical and immunophenotyping study.Journal of anatomy · 2016Article
- A novel immunopathological association of IgG4-RD and vasculitis with Hashimoto's thyroiditis.Endocrinology, diabetes & metabolism case reports · 2016Article
- Immunoglobulin G4-related sclerosing cholecystitis presenting as gallbladder cancer: a case report.Surgical case reports · 2015Article
- Isolated Liver Hilar Infiltration by IgG4 Inflammation Mimicking Cholangiocarcinoma.Case reports in gastroenterologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have proposed nomenclatures of type 1 autoimmune pancreatitis (AIP) (IgG4-related pancreatitis), IgG4-related sclerosing cholangitis (IgG4-SC), IgG4-related cholecystitis, and IgG4-related hepatopathy as IgG4-related disease (IgG4-RD) in the hepato-bilio-pancreatic system. In IgG4-related hepatopathy, a novel concept of IgG4-related autoimmune hepatitis (AIH) with the same histopathological features as AIH has been proposed. Among organs involved in IgG4-RD, associations with pancreatic and biliary lesions are most frequently observed, supporting the novel concept of "biliary diseases with pancreatic counterparts." Targets of type 1 AIP and IgG4-SC may be periductal glands around the bile and pancreatic ducts. Based on genetic backgrounds, innate and acquired immunity, Th2-dominant immune status, regulatory T (Treg) or B cells, and complement activation via a classical pathway may be involved in the development of IgG4-RD. Although the role of IgG4 remains unclear in IgG4-RD, IgG4-production is upregulated by interleukin 10 from Treg cells and by B cell activating factor from monocytes/basophils with stimulation of toll-like receptors/nucleotide-binding oligomerization domain-like receptors. Based on these findings, we have proposed a hypothesis for the development of IgG4-RD in the hepato-bilio-pancreatic system. Further studies are necessary to clarify the pathogenic mechanism of IgG4-RD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.