ReviewFrontiers in physiology2014
Metabolism leaves its mark on the powerhouse: recent progress in post-translational modifications of lysine in mitochondria.
Review in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 84 citations in OpenAlex.
- Beyond acetylation: Evaluating the emerging biology of lysine acylation.Cell chemical biology · 2026Review
- Succinylation: novel molecular mechanisms and prospects for targeted therapy in liver diseases.Frontiers in molecular biosciences · 2026Review
- Review
- Bioluminescence assay of lysine deacylase sirtuin activity.Cell chemical biology · 2024Article
- Succinylation of 14-3-3 theta by CPT1A promotes survival and paclitaxel resistance in nasal type extranodal natural killer/T-cell lymphoma.Translational oncology · 2024Article
- Protein succinylation, hepatic metabolism, and liver diseases.World journal of hepatology · 2024Review
- Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities.Genes & diseases · 2023Review
- pSuc-EDBAM: Predicting lysine succinylation sites in proteins based on ensemble dense blocks and an attention module.BMC bioinformatics · 2022Article
- The histone code of the fungal genusMicrobial genomics · 2022Article
- Deep Neural Network Framework Based on Word Embedding for Protein Glutarylation Sites Prediction.Life (Basel, Switzerland) · 2022Article
- Review
- A New Target of the Four-Herb Chinese Medicine for Wound Repair Promoted by Mitochondrial Metabolism Using Protein Acetylation Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Proteomic analysis of alcohol-associated hepatitis reveals glycoprotein NMB (GPNMB) as a novel hepatic and serum biomarker.Alcohol (Fayetteville, N.Y.) · 2022Article
- iSuc-ChiDT: a computational method for identifying succinylation sites using statistical difference table encoding and the chi-square decision table classifier.BioData mining · 2022Article
- Sirtuin 4 Inhibits Prostate Cancer Progression and Metastasis by Modulating p21 Nuclear Translocation and Glutamate Dehydrogenase 1 ADP-Ribosylation.Journal of oncology · 2022Article
- 3D-printed oxygen-releasing scaffolds improve bone regeneration in mice.Biomaterials · 2022Article
- Protein acetylation in cardiac aging.Journal of molecular and cellular cardiology · 2021Review
- MDCAN-Lys: A Model for Predicting Succinylation Sites Based on Multilane Dense Convolutional Attention Network.Biomolecules · 2021Article
- First comprehensive analysis of lysine succinylation in paper mulberry (Broussonetia papyrifera).BMC genomics · 2021Article
- Iron overload adversely effects bone marrow haematogenesis via SIRT-SOD2-mROS in a process ameliorated by curcumin.Cellular & molecular biology letters · 2021Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
Lysine modifications have been studied extensively in the nucleus, where they play pivotal roles in gene regulation and constitute one of the pillars of epigenetics. In the cytoplasm, they are critical to proteostasis. However, in the last decade we have also witnessed the emergence of mitochondria as a prime locus for post-translational modification (PTM) of lysine thanks, in large measure, to evolving proteomic techniques. Here, we review recent work on evolving set of PTM that arise from the direct reaction of lysine residues with energized metabolic thioester-coenzyme A intermediates, including acetylation, succinylation, malonylation, and glutarylation. We highlight the evolutionary conservation, kinetics, stoichiometry, and cross-talk between members of this emerging family of PTMs. We examine the impact on target protein function and regulation by mitochondrial sirtuins. Finally, we spotlight work in the heart and cardiac mitochondria, and consider the roles acetylation and other newly-found modifications may play in heart disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.