Evidence map›Paper›PMID 25228675›Full record

ArticleBMJ case reports2014

Fluoroquinolone use in a child associated with development of osteochondritis dissecans.

John C Jacobs, Kevin G Shea, Julia Thom Oxford, James L Carey

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

John C JacobsUniversity of Utah School of Medicine, Salt Lake City, Utah.
Kevin G SheaSt. Luke's Boise Medical Center, Boise, Idaho, USA Department of Orthopedics, University of Utah, Salt Lake City, Utah, USA.
Julia Thom OxfordBoise State University, Boise, Idaho, USA.ORCID http://orcid.org/0000-0002-4850-3569
James L CareyPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
University of Utah · USBoise State University · USUniversity of Pennsylvania · US

Funding

Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote WestP20GM103408 · NIGMS · UNIVERSITY OF IDAHO · PI Scott A Minnich · 2012 to 2026
$59.8M
UNDERGRADUATE COLLEGE OUTREACH PROGRAMP20RR016454 · NCRR · UNIVERSITY OF IDAHO · PI CHASE, JENNIFER R · 2001 to 2011
$35.3M
VPS35 D620N inhibits autophagy through disrupted hyaluronic acid-CD44 signalingP20GM109095 · NIGMS · BOISE STATE UNIVERSITY · PI OXFORD, JULIA THOM · 2014 to 2023
$22.7M
Type XI collagen isoforms in skeletal biologyR01AR047985 · NIAMS · BOISE STATE UNIVERSITY · PI OXFORD, JULIA T · 2001 to 2005
$1.3M
Type XI collagen isoforms in skeletal biologyK02AR048672 · NIAMS · BOISE STATE UNIVERSITY · PI OXFORD, JULIA T · 2002 to 2006
$376k
Regulation of cell signaling by Col11a1 during craniofacial development in the zeR15HD059949 · NICHD · BOISE STATE UNIVERSITY · PI OXFORD, JULIA THOM · 2009 to 2009
$212k
NCRR NIH HHS P20 RR016454NIAMS NIH HHS K02 AR048672NIAMS NIH HHS R01 AR047985NICHD NIH HHS R15 HD059949NIGMS NIH HHS P20 GM103408NIGMS NIH HHS P20 GM109095
6 · The paper itself

Abstract

Several aetiological theories have been proposed for the development of osteochondritis dissecans. Cartilage toxicity after fluoroquinolone use has been well documented in vitro. We present a case report of a 10-year-old child who underwent a prolonged 18-month course of ciprofloxacin therapy for chronic urinary tract infections. This patient later developed an osteochondritis dissecans lesion of the medial femoral condyle. We hypothesise that the fluoroquinolone therapy disrupted normal endochondral ossification, resulting in development of osteochondritis dissecans. The aetiology of osteochondritis dissecans is still unclear, and this case describes an association between fluoroquinolone use and osteochondritis dissecans development.

Indexed as

Anti-Bacterial AgentsChildChronic DiseaseDrug Administration ScheduleFemaleFluoroquinolonesHumansOsteochondritis DissecansUrinary Tract InfectionsAnti-Bacterial AgentsFluoroquinolones

Identifiers

PMID25228675
PMCPMC4166236
OpenAlexW2011788528

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.