ArticleGenes & development2014
Repression of the soma-specific transcriptome by Polycomb-repressive complex 2 promotes male germ cell development.
Article in Genes & development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 109 citations in OpenAlex.
- Dynamic regulation of spermatogenesis and hybrid sterility revealed by single-cell analysis in yak and cattle.Molecular biology and evolution · 2026Article
- The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice.Nature communications · 2025Article
- An Epigenomic Roadmap Primes Non-Growing Oocytes for Maturation and Early Embryogenesis.bioRxiv : the preprint server for biology · 2025Article
- Metastasis-associated lung adenocarcinoma transcript 1 overexpression in testis contributes to idiopathic non-obstructive azoospermia via repressing ETS variant transcription factor 5.Molecular biomedicine · 2024Article
- Epigenetic priming in the male germline.Current opinion in genetics & development · 2024Review
- Prenatal exposure to Di(2-ethylhexyl) phthalate and high-fat diet synergistically disrupts gonadal function in male mice†.Biology of reproduction · 2024Article
- PRC1 directs PRC2-H3K27me3 deposition to shield adult spermatogonial stem cells from differentiation.Nucleic acids research · 2024Article
- KDM6A/UTX promotes spermatogenic gene expression across generations and is not required for male fertility†.Biology of reproduction · 2024Article
- Article
- Chromosome-specific maturation of the epigenome in the Drosophila male germline.bioRxiv : the preprint server for biology · 2023Article
- PRC1 suppresses a female gene regulatory network to ensure testicular differentiation.Cell death & disease · 2023Article
- Cell type-specific role of CBX2 and its disordered region in spermatogenesis.Genes & development · 2023Article
- Epigenetic regulation of embryonic ectoderm development in stem cell differentiation and transformation during ontogenesis.Cell proliferation · 2023Review
- Chromatin Remodeling via Retinoic Acid Action during Murine Spermatogonial Development.Life (Basel, Switzerland) · 2023Article
- Estrogenic and Non-Estrogenic Disruptor Effect of Zearalenone on Male Reproduction: A Review.International journal of molecular sciences · 2023Review
- Inhibition of EED activity enhances cell survival of female germline stem cell and improves the oocytes production during oogenesisOpen biology · 2023Article
- Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-κB p65 pathway.Acta pharmacologica Sinica · 2022Article
- RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expression.G3 (Bethesda, Md.) · 2022Article
- Identification and characterization of BEND2 as a key regulator of meiosis during mouse spermatogenesis.Science advances · 2022Article
- INO80 requires a polycomb subunit to regulate the establishment of poised chromatin in murine spermatocytes.Development (Cambridge, England) · 2022Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Polycomb-repressive complex 2 (PRC2) catalyzes the methylation of histone H3 Lys27 (H3K27) and functions as a critical epigenetic regulator of both stem cell pluripotency and somatic differentiation, but its role in male germ cell development is unknown. Using conditional mutagenesis to remove the core PRC2 subunits EED and SUZ12 during male germ cell development, we identified a requirement for PRC2 in both mitotic and meiotic germ cells. We observed a paucity of mutant spermatogonial stem cells (SSCs), which appears independent of repression of the known cell cycle inhibitors Ink4a/Ink4b/Arf. Moreover, mutant spermatocytes exhibited ectopic expression of somatic lamins and an abnormal distribution of SUN1 proteins on the nuclear envelope. These defects were coincident with abnormal chromosome dynamics, affecting homologous chromosome pairing and synapsis. We observed acquisition of H3K27me3 on stage-specific genes during meiotic progression, indicating a requirement for PRC2 in regulating the meiotic transcriptional program. Together, these data demonstrate that transcriptional repression of soma-specific genes by PRC2 facilitates homeostasis and differentiation during mammalian spermatogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.