Evidence map›Paper›PMID 25228593›Full record

ArticleDatabase : the journal of biological databases and curation2014

RADB: a database of rheumatoid arthritis-related polymorphisms.

Ruijie Zhang, Meiwei Luan, Zhenwei Shang, Lian Duan, Guoping Tang, Miao Shi, Wenhua Lv, Hongjie Zhu, Jin Li, Hongchao Lv and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Database : the journal of biological databases and curation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Ruijie ZhangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China, Yiwu Hospital, Zhejiang University, Yiwu 322000, China, Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China, Depatment of Pathology, Harbin Medical University, Harbin 150086, China jiangyongshuai@gmail.com.
Meiwei LuanCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China, Yiwu Hospital, Zhejiang University, Yiwu 322000, China, Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China, Depatment of Pathology, Harbin Medical University, Harbin 150086, China.
Zhenwei ShangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China, Yiwu Hospital, Zhejiang University, Yiwu 322000, China, Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China, Depatment of Pathology, Harbin Medical University, Harbin 150086, China.
Lian DuanCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China, Yiwu Hospital, Zhejiang University, Yiwu 322000, China, Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China, Depatment of Pathology, Harbin Medical University, Harbin 150086, China.
Guoping TangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China, Yiwu Hospital, Zhejiang University, Yiwu 322000, China, Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China, Depatment of Pathology, Harbin Medical University, Harbin 150086, China.
Miao ShiCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China, Yiwu Hospital, Zhejiang University, Yiwu 322000, China, Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China, Depatment of Pathology, Harbin Medical University, Harbin 150086, China.
Wenhua LvCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China, Yiwu Hospital, Zhejiang University, Yiwu 322000, China, Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China, Depatment of Pathology, Harbin Medical University, Harbin 150086, China.
Hongjie ZhuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China, Yiwu Hospital, Zhejiang University, Yiwu 322000, China, Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China, Depatment of Pathology, Harbin Medical University, Harbin 150086, China.
Jin LiCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China, Yiwu Hospital, Zhejiang University, Yiwu 322000, China, Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China, Depatment of Pathology, Harbin Medical University, Harbin 150086, China.
Hongchao LvCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China, Yiwu Hospital, Zhejiang University, Yiwu 322000, China, Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China, Depatment of Pathology, Harbin Medical University, Harbin 150086, China.
Mingming ZhangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China, Yiwu Hospital, Zhejiang University, Yiwu 322000, China, Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China, Depatment of Pathology, Harbin Medical University, Harbin 150086, China.
Guiyou LiuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China, Yiwu Hospital, Zhejiang University, Yiwu 322000, China, Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China, Depatment of Pathology, Harbin Medical University, Harbin 150086, China.
He ChenCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China, Yiwu Hospital, Zhejiang University, Yiwu 322000, China, Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China, Depatment of Pathology, Harbin Medical University, Harbin 150086, China zhangruijie 2013@gmail.com chenhe201406@163.com.
Yongshuai JiangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China, Yiwu Hospital, Zhejiang University, Yiwu 322000, China, Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China, Depatment of Pathology, Harbin Medical University, Harbin 150086, China jiangyongshuai@gmail.com.
Harbin Medical University · CNTianjin Institute of Industrial Biotechnology · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease that has a complex genetic basis. Therefore, it is important to explore the genetic background of RA. The extensive recent application of polymorphic genetic markers, especially single nucleotide polymorphisms, has presented us with a large quantity of genetic data. In this study, we developed the Database of Rheumatoid Arthritis-related Polymorphisms (RADB), to integrate all the RA-related genetic polymorphisms and provide a useful resource for researchers. We manually extracted the RA-related polymorphisms from 686 published reports, including RA susceptibility loci, polymorphisms associated with particular clinical features of RA, polymorphisms associated with drug response in RA and polymorphisms associated with a higher risk of cardiovascular disease in RA. Currently, RADB V1.0 contains 3235 polymorphisms that are associated with 636 genes and refer to 68 countries. The detailed information extracted from the literature includes basic information about the articles (e.g., PubMed ID, title and abstract), population information (e.g., country, geographic area and sample size) and polymorphism information (e.g., polymorphism name, gene, genotype, odds ratio and 95% confidence interval, P-value and risk allele). Meanwhile, useful annotations, such as hyperlinks to dbSNP, GenBank, UCSC, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway, are included. In addition, a tool for meta-analysis was developed to summarize the results of multiple studies. The database is freely available at http://www.bioapp.org/RADB. Database URL: http://www.bioapp.org/RADB.

Indexed as

Databases, GeneticInternetAntirheumatic AgentsArthritis, RheumatoidCardiovascular DiseasesGene OntologyGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPolymorphism, GeneticRiskSoftwareUser-Computer InterfaceAntirheumatic Agents

Identifiers

PMID25228593
PMCPMC4164886
OpenAlexW2164835760

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.