ArticleInvestigative ophthalmology & visual science2014
Nerve fiber layer thinning lags retinal ganglion cell density following crush axonopathy.
Article in Investigative ophthalmology & visual science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
- Trial
- Longitudinal Structural and Microvascular Imaging of Mouse Retina After Optic Nerve Crush Using Temporal Speckle-Averaging Visible Light OCT.Investigative ophthalmology & visual science · 2025Article
- Neuroprotective effect of ripasudil on retinal ganglion cells via an antioxidative mechanism.Japanese journal of ophthalmology · 2025Article
- Article
- Amyloid-β-induced pyroptosis drives retinal neurodegeneration in a TgAPPswePS1 mouse model.International journal of ophthalmology · 2025Article
- Confocal Scanning Laser Ophthalmoscopy to Image Retinal Ganglion Cells in Real-Time.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Progression of optic atrophy in traumatic optic neuropathy: retrograde neuronal degeneration in humans.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Comparison of optical coherence tomography angiography metrics in primary angle-closure glaucoma and normal-tension glaucoma.Scientific reports · 2021Article
- The Impact of Superficial Vessel Density on Glaucoma Progression according to the Stage of Glaucoma.Journal of clinical medicine · 2021Article
- Establishing the ground squirrel as a superb model for retinal ganglion cell disorders and optic neuropathies.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- Deep Learning-Based Retinal Nerve Fiber Layer Thickness Measurement of Murine Eyes.Translational vision science & technology · 2021Article
- Long-Term Effects of a Photodisruptive Laser-Induced Traumatic Neuropathy Model.Translational vision science & technology · 2021Article
- Retinal ganglion cell ablation in guinea pigs.Experimental eye research · 2021Article
- Retinal imaging in Alzheimer's and neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Review
- Ovariectomy worsens visual function after mild optic nerve crush in rodents.Experimental eye research · 2021Article
- Endogenous ocular lipids as potential modulators of intraocular pressure.Journal of cellular and molecular medicine · 2020Article
- Longitudinal detection of retinal alterations by visible and near-infrared optical coherence tomography in a dexamethasone-induced ocular hypertension mouse model.Neurophotonics · 2019Article
- Peripapillary Vessel Density In Unilateral Preperimetric Glaucoma.Clinical ophthalmology (Auckland, N.Z.) · 2019Article
- Response of the Retinal Nerve Fiber Layer Reflectance and Thickness to Optic Nerve Crush.Investigative ophthalmology & visual science · 2018Article
- Wnt signaling promotes axonal regeneration following optic nerve injury in the mouse.Neuroscience · 2017Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
purposeWe investigated the progressive nature of neurodegenerative structural changes following injury to retinal ganglion cell (RGC) axons using quantifiable and noninvasive in vivo imaging techniques.
methodsTo track degenerative RGC progression in retinas following optic nerve crush (ONC) injury, spectral-domain optical coherence tomography (SD-OCT) was used to quantitate the RGC nerve fiber layer (NFL) density. The RGC soma cell density (RCD) was measured by confocal scanning laser ophthalmoscopy (CSLO). The RCD counts were performed using blood vessels as landmarks to anatomically track defined progressive changes in enhanced yellow fluorescent fusion protein (EYFP)-labeled RGCs.
resultsFollowing ONC injury, 68% of the observed decrease in RCD measured by CSLO and 54% of the NFL thickness obtained by SD-OCT imaging (N=4 retinas) occurred within the first week. Between days 7 and 14, an additional 22% decrease in RCD was concurrent with a 31% decrease in overall NFL thickness. Finally, between days 14 and 21, an additional 10% decrease in RCD measured in vivo by CSLO and 15% decrease in NFL thickness by SD-OCT was observed.
conclusionsOur data suggest that in vivo CSLO imaging of EYFP-RGC expression and SD-OCT measured NFL thickness are fast and reliable methods that longitudinally track neurodegenerative progression following ONC injury. Neurodegenerative changes in NFL thickness measured by SD-OCT imaging have the same overall trajectory as those observed by CSLO for RCD; however, changes in NFL thickness initially lag behind in vivo RGC soma counts with a slower decline in overall measurable change.
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