Evidence map›Paper›PMID 25228456›Full record

ArticleBritish journal of clinical pharmacology2015

Safety of intravenous β-adrenoceptor blockers for computed tomographic coronary angiography.

Benjamin Clayton, Vikram Raju, Carl Roobottom, Gareth Morgan-Hughes

Open access · bronzeAbstract read
In one paragraph

Article in British journal of clinical pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Benjamin ClaytonCardiology Department, Derriford Hospital, Plymouth, PL6 8DH, UK.
Vikram Raju
Carl Roobottom
Gareth Morgan-Hughes
Derriford Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo assess the safety of our clinical practice using off-label intravenous metoprolol to facilitate computed tomographic (CT) coronary angiography.

methodsA retrospective analysis of scan reports and hospital admissions data was conducted to identify adverse events occurring following CT coronary angiography in patients who had received intravenous metoprolol prior to the scan.

resultsA total of 3098 patients were included, of whom 1871 received intravenous metoprolol. Nine hundred and one patients received more than 15 mg and 129 patients received metoprolol despite a resting heart rate <65 beats min(-1) . There was a single adverse incident, comprising transient loss of consciousness.

conclusionsThe use of intravenous metoprolol to facilitate cardiac CT scanning appears safe. Dose limits recommended for other indications, generally in acutely unwell patients, may not need to be as stringent in this population.

Indexed as

Off-Label UseAdrenergic beta-AntagonistsCoronary AngiographyDose-Response Relationship, DrugHeart RateHumansMetoprololRetrospective StudiesTomography, X-Ray ComputedAdrenergic beta-AntagonistsMetoprololadrenergic β-adrenoceptor antagonistscoronary angiographydrug-related side effects and adverse reactionsmetoprololtomographyX-ray computed

Identifiers

PMID25228456
PMCPMC4345963
OpenAlexW1539366391

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.