ArticleParasites & vectors2014
A new multiple-locus variable-number tandem repeat analysis reveals different clusters for Anaplasma phagocytophilum circulating in domestic and wild ruminants.
Article in Parasites & vectors, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Host-pathogen associations revealed by genotyping of European strains of Anaplasma phagocytophilum to describe natural endemic cycles.Parasites & vectors · 2023Article
- The role of sheep ked (Melophagus ovinus) as potential vector of protozoa and bacterial pathogens.Scientific reports · 2021Article
- Epidemiological and Clinicopathological Features ofFrontiers in veterinary science · 2021Review
- A review on the eco-epidemiology and clinical management of human granulocytic anaplasmosis and its agent in Europe.Parasites & vectors · 2019Review
- Presence of Roe Deer Affects the Occurrence ofInternational journal of environmental research and public health · 2019Article
- Anaplasma phagocytophilum evolves in geographical and biotic niches of vertebrates and ticks.Parasites & vectors · 2019Article
- Diverse tick-borne microorganisms identified in free-living ungulates in Slovakia.Parasites & vectors · 2018Article
- Co-circulation of different A. phagocytophilum variants within cattle herds and possible reservoir role for cattle.Parasites & vectors · 2018Article
- Epidemiology, genetic variants and clinical course of natural infections with Anaplasma phagocytophilum in a dairy cattle herd.Parasites & vectors · 2018Article
- Zoonotic Babesia microti in the northeastern U.S.: Evidence for the expansion of a specific parasite lineage.PloS one · 2018Article
- Emergence of tick-borne diseases at northern latitudes in Europe: a comparative approach.Scientific reports · 2017Article
- Detecting and characterizing mixed infections with genetic variants of Anaplasma phagocytophilum in roe deer (Capreolus capreolus) by developing an ankA cluster-specific nested PCR.Parasites & vectors · 2017Article
- One particular Anaplasma phagocytophilum ecotype infects cattle in the Camargue, France.Parasites & vectors · 2017Article
- Anaplasma spp. in dogs and owners in north-western Morocco.Parasites & vectors · 2017Article
- Multiple-locus variable-number tandem repeat analysis potentially reveals the existence of two groups of Anaplasma phagocytophilum circulating in cattle in France with different wild reservoirs.Parasites & vectors · 2016Article
- Serologic screening for 13 infectious agents in roe deer (Capreolus capreolus) in Flanders.Infection ecology & epidemiology · 2015Article
- Opening the black box of Anaplasma phagocytophilum diversity: current situation and future perspectives.Frontiers in cellular and infection microbiology · 2015Review
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Authors and funding
15 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnaplasma phagocytophilum is a tick-borne intragranulocytic alpha-proteobacterium. It is the causative agent of tick-borne fever in ruminants, and of human granulocytic anaplasmosis in humans, two diseases which are becoming increasingly recognized in Europe and the USA. However, while several molecular typing tools have been developed over the last years, few of them are appropriate for in-depth exploration of the epidemiological cycle of this bacterium. Therefore we have developed a Multiple-Locus Variable number tandem repeat (VNTR) Analysis typing technique for A. phagocytophilum.
methodsFive VNTRs were selected based on the HZ human-derived strain genome, and were tested on the Webster human-derived strain and on 123 DNA samples: 67 from cattle, 7 from sheep, 15 from roe deer, 4 from red deer, 1 from a reindeer, 2 from horses, 1 from a dog, and 26 from ticks.
resultsFrom these samples, we obtained 84 different profiles, with a diversity index of 0.96 (0.99 for vertebrate samples, i.e. without tick samples). Our technique confirmed that A. phagocytophilum from roe deer or domestic ruminants belong to two different clusters, while A. phagocytophilum from red deer and domestic ruminants locate within the same cluster, questioning the respective roles of roe vs red deer as reservoir hosts for domestic ruminant strains in Europe. As expected, greater diversity was obtained between rather than within cattle herds.
conclusionsOur technique has great potential to provide detailed information on A. phagocytophilum isolates, improving both epidemiological and phylogenic investigations, thereby helping in the development of relevant prevention and control measures.
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