ArticleThe Plant cell2014
BBX19 interacts with CONSTANS to repress FLOWERING LOCUS T transcription, defining a flowering time checkpoint in Arabidopsis.
Article in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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Who cites it
80 citing papers in PubMed.
- SlBBX19 modulates plant development and negatively regulates chilling tolerance in tomato.The Plant journal : for cell and molecular biology · 2026Article
- Multifaceted roles of BBX transcription factors: impacts on key agronomical traits and environmental resilience.The New phytologist · 2026Review
- Genome-wide analysis of PfBBXs transcription factors in Perilla frutescens and their expression responses to different light intensities.Plant molecular biology · 2025Article
- The CONSTANS-like gene family in wheat is involved in heading date and drought stress response.Scientific reports · 2025Article
- Seasonal changes in daily temperature fluctuation control flowering through a time-dependent regulation ofResearch square · 2025Article
- BBX24 and BBX25 antagonize the function of thermosensor ELF3 to promote PIF4-mediated thermomorphogenesis in Arabidopsis.Plant communications · 2025Article
- OsBBX2 Delays Flowering by RepressingPlants (Basel, Switzerland) · 2024Article
- Identification of superior haplotypes for flowering time in pigeonpea through candidate gene-based association study of a diverse minicore collection.Plant cell reports · 2024Article
- Epigenetic regulation of photoperiodic flowering in plants.The plant genome · 2023Review
- Involvement of CONSTANS-like Proteins in Plant Flowering and Abiotic Stress Response.International journal of molecular sciences · 2023Review
- Genome resequencing reveals the evolutionary history of garlic reproduction traits.Horticulture research · 2023Article
- Transcriptome Analysis Reveals Key Genes and Pathways Associated with the Regulation of Flowering Time in Cabbage (Plants (Basel, Switzerland) · 2023Article
- Genome-Wide Analysis of theInternational journal of molecular sciences · 2023Article
- Photoperiodic flowering in Arabidopsis: Multilayered regulatory mechanisms of CONSTANS and the florigen FLOWERING LOCUS T.Plant communications · 2023Review
- The Transcription FactorsInternational journal of molecular sciences · 2023Article
- BBX7 interacts with BBX8 to accelerate flowering in chrysanthemum.Molecular horticulture · 2023Article
- Characterization and expression profiles of the B-box gene family during plant growth and under low-nitrogen stress in Saccharum.BMC genomics · 2023Article
- Genome-Wide Characterization of B-Box Gene Family inInternational journal of molecular sciences · 2023Article
- Multi-layered roles of BBX proteins in plant growth and development.Stress biology · 2023Review
- Genetic analysis of phenotypic plasticity identifiesFrontiers in plant science · 2023Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The timely transition of vegetative to reproductive development is coordinated through quantitative regulation of floral pathway genes in response to physiological and environmental cues. Here, we show that the circadian-controlled expression of the Arabidopsis thaliana floral transition regulators FLOWERING LOCUS T (FT) and CONSTANS (CO) is antiphasic to that of BBX19, a transcription factor with two B-Box motifs. Diminished expression of BBX19 by RNA interference accelerates flowering, and constitutive expression of BBX19 delays flowering under inductive photoperiods. This delay is not accompanied by the alteration of CO expression levels but rather by a reduction of transcript levels of FT and the FT-regulated genes SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1, LEAFY, and FRUITFUL. Similar to CO, BBX19 is expressed in vasculature. BBX19 and CO colocalize in the nucleus and interact physically in vivo. In transient assays, coinfiltration of 10-fold more CO overcomes the BBX19-mediated repression of FT activation. Substitution of the conserved Cys-25 to Ser in the BBX19 Box1 motif abolishes the BBX19-CO interaction and eliminates the negative regulation of flowering time, while the analogous C76S substitution in the Box2 motif is ineffective. Together, these results implicate BBX19 as a circadian clock output that depletes the active CO pool to accurately monitor daylength and precisely time FT expression.
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