ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2015
Contribution of symptom clusters to multiple sclerosis consequences.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Sleep and cognitive outcomes in multiple sclerosis; a systematic review.BMC psychiatry · 2024Pooled it
- Pooled it
- Non-invasive Brain and Spinal Stimulation for Pain and Related Symptoms in Multiple Sclerosis: A Systematic Review.Frontiers in neuroscience · 2020Pooled it
- Sleep Disturbance and Cognitive Dysfunction in Multiple Sclerosis: a Systematic Review.Current neurology and neuroscience reports · 2018Pooled it
- Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis.Journal of visualized experiments : JoVE · 2016Trial
- Effectiveness of a self-management educational program among people with multiple sclerosis: a pre-test post-test intervention study.The Journal of the Egyptian Public Health Association · 2026Article
- Phenotypic Diversity in Multiple Sclerosis Can Be Represented by Four Additive Symptom Modules.Brain sciences · 2026Article
- A Review of the Impact of Platform Therapies (DMTs) on Associated Clinical Symptoms of Multiple Sclerosis.Journal of multidisciplinary healthcare · 2025Review
- Influence of Education, Cognition, and Physical Disability on Quality of Life of Romanian Patients with Multiple Sclerosis-A Cohort Study.Medicina (Kaunas, Lithuania) · 2024Article
- The impact of fatigue on people with multiple sclerosis in Morocco.African journal of disability · 2024Article
- Spasticity-Plus syndrome in multiple sclerosis patients in a tertiary hospital in Spain.Frontiers in neurology · 2024Article
- Social stigma and its relationship with quality of life in multiple sclerosis patients.BMC neurology · 2023Article
- A scoping review of the clinical application of machine learning in data-driven population segmentation analysis.Journal of the American Medical Informatics Association : JAMIA · 2023Article
- Cognitive rehabilitation in multiple sclerosis: Three digital ingredients to address current and future priorities.Frontiers in human neuroscience · 2023Review
- Symptom Interconnectivity in Multiple Sclerosis: A Narrative Review of Potential Underlying Biological Disease Processes.Neurology and therapy · 2022Review
- Demographic Patterns of MS Patients Using BRISA: An MS-Specific App in Germany.Journal of personalized medicine · 2022Article
- Do physical activity and social cognitive theory variable scores differ across symptom cluster severity groups in multiple sclerosis?Disability and health journal · 2021Article
- Therapeutic Attributes of Endocannabinoid System against Neuro-Inflammatory Autoimmune Disorders.Molecules (Basel, Switzerland) · 2021Review
- Symptom clusters and quality of life in persons with multiple sclerosis across the lifespan.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Association between fatigue, pain, digestive problems, and sleep disturbances and individuals' health-related quality of life: a nationwide survey in South Korea.Health and quality of life outcomes · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeThere were two objectives in this study: (1) to identify, among women and men with MS, the extent to which different MS-related symptoms, including fatigue, pain, sleep disturbance, depression, anxiety, irritability, cognitive impairment, spasticity, and poor balance, cluster and (2) to compare the contribution of generated symptom clusters to MS consequences including functional walking capacity, perceived health, illness intrusiveness, and quality of life (QOL).
methodsThis was a cross-sectional study. A center-stratified random sample comprising 139 women and 49 men was recruited from three major MS clinics in Montreal. Subjects completed several self-report and performance-based measures that assessed symptoms and downstream MS consequences. Hierarchical and K-means cluster analyses were used to create clusters.
resultsThree symptom clusters were identified. Cluster 1, labeled the "emotional/cognitive symptom cluster," comprised of depression, anxiety, cognitive impairments, and irritability. The second cluster, labeled the "physical symptom cluster," included pain, fatigue, and sleep disorders. Cluster 3, labeled the "motor symptom cluster," included spasticity and poor balance. Furthermore, the motor symptom cluster had a strong effect on functional walking capacity, while it did not affect significantly illness intrusiveness and QOL. On the other hand, the physical symptom clusters and emotional/cognitive symptom clusters showed a significant contribution to prediction of illness intrusiveness and QOL. All symptom clusters showed a significant effect in predicting the overall variability of perceived health status.
conclusionsThe findings of this study provide useful information to help healthcare professionals, clinicians, and researchers to target symptoms that are often in the same cluster when one or two of them are present. Identification of the strength of the contributions of each symptom clusters to the targeted MS consequences would further help to prioritize treatment approaches for the MS population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.