ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2015
Pttg1 inhibits TGFβ signaling in breast cancer cells to promote their growth.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- MicroRNA in Acromegaly: Involvement in the Pathogenesis and in the Response to First-Generation Somatostatin Receptor Ligands.International journal of molecular sciences · 2022Review
- Conditional transcriptional relationships may serve as cancer prognostic markers.BMC medical genomics · 2021Article
- Suppression of PTTG1 inhibits cell angiogenesis, migration and invasion in glioma cells.Medical oncology (Northwood, London, England) · 2020Article
- Estrogen-regulated PTTG1 promotes breast cancer progression by regulating cyclin kinase expression.Molecular medicine (Cambridge, Mass.) · 2020Article
- Inhibition of TGF-β Signaling in Gliomas by the Flavonoid Diosmetin Isolated fromMolecules (Basel, Switzerland) · 2020Article
- microRNA-Dependent Modulation of Genes Contributes to ESR1's Effect on ERα Positive Breast Cancer.Frontiers in oncology · 2020Article
- Targeting theOncotarget · 2017Article
- Increased miR-338-3p expression correlates with invasiveness of GH-producing pituitary adenomas.Endocrine · 2017Article
- Pituitary tumor-transforming gene 1 enhances metastases of cervical cancer cells through miR-3666-regulated ZEB1.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Pituitary tumor-transforming gene 1 regulates invasion of prostate cancer cells through MMP13.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Histone deacetylase 6 promotes growth of glioblastoma through inhibition of SMAD2 signaling.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
Corrections and comments
- Retraction · 2017-04-20Compromised Peer Review · Investigation by Journal/Publisher · · Journal published by SAGE starting in 2017
- Retracted
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased expression of Pituitary Tumor Transforming Gene 1 (Pttg1) has been shown in various tumor cells, including breast cancer (BC). However, the precise role of Pttg1 in the tumorigenesis is not clarified yet. Here, we examined BC from the patients and detected significant increases and correlation in Pttg1 and phosphorylated SMAD3 (pSMAD3), a key effector of activated transforming growth factor β (TGFβ) receptor signaling pathway. Pttg1 levels were then modulated by transgene or small hairpin RNA (shRNA) in a human BC cell line, BT474, respectively. We found that Pttg1 overexpression increased the proliferation of BC cells in vitro and in vivo, while Pttg1 inhibition decreased proliferation of BC cells in vitro and in vivo. Moreover, phosphorylation of SMAD3 by TGFβ1 was significantly inhibited by Pttg1 overexpression, suggesting that Pttg1 may promote growth of BC cells by inhibiting pSMAD3-mediated cell-growth inhibition. Thus, Pttg1 appears to be a novel therapeutic target for controlling the tumorigenesis of BC.
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