De-escalation as a potential way of reducing antibiotic use and antimicrobial resistance in ICU.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Strategies to reduce curative antibiotic therapy in intensive care units (adult and paediatric).Intensive care medicine · 2015
   Guideline
2. An agent-based model on antimicrobial de-escalation in intensive care units: Implications on clinical trial design.PloS one · 2024
   Article
3. Impact of prior antibiotics on infected pancreatic necrosis microbiology in ICU patients: a retrospective cohort study.Annals of intensive care · 2020
   Article
4. Use of oral third generation cephalosporins and quinolones and occurrence of antibiotic-resistant strains in the neurogenic bladder (NB) outpatient setting: a retrospective chart audit.Spinal cord · 2020
   Article
5. Antimicrobial de-escalation is part of appropriate antibiotic usage in ICU.Intensive care medicine · 2020
   Article
6. Antipathy against SDD is justified: Yes.Intensive care medicine · 2018
   Article
7. Antibiotics De-Escalation in the Treatment of Ventilator-Associated Pneumonia in Trauma Patients: A Retrospective Study on Propensity Score Matching Method.Chinese medical journal · 2018
   Article
8. Summary of the international clinical guidelines for the management of hospital-acquired and ventilator-acquired pneumonia.ERJ open research · 2018
   Article
9. Benefits and unintended consequences of antimicrobial de-escalation: Implications for stewardship programs.PloS one · 2017
   Article
10. How to measure the impacts of antibiotic resistance and antibiotic development on empiric therapy: new composite indices.BMJ open · 2016
    Article
11. Understanding antibiotic stewardship for the critically ill.Intensive care medicine · 2016
    Article
12. Does this patient have VAP?Intensive care medicine · 2016
    Article
13. Characteristics and outcomes of anti-infective de-escalation during health care-associated intra-abdominal infections.Critical care (London, England) · 2016
    Article
14. Pros and cons of using biomarkers versus clinical decisions in start and stop decisions for antibiotics in the critical care setting.Intensive care medicine · 2015
    Review
15. A Simulation Study Reveals Lack of Pharmacokinetic/Pharmacodynamic Target Attainment in De-escalated Antibiotic Therapy in Critically Ill Patients.Antimicrobial agents and chemotherapy · 2015
    Article
16. Preventive and therapeutic strategies in critically ill patients with highly resistant bacteria.Intensive care medicine · 2015
    Review
17. If antibiotics did not exist.Intensive care medicine · 2015
    Article

Corrections and comments

• Comment on
  De-escalation versus continuation of empirical antimicrobial treatment in severe sepsis: a multicenter non-blinded randomized noninferiority trial.2014

Authors and funding

3 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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