Evidence map›Paper›PMID 25227629›Full record

ArticleBMJ open2014

A prospective cohort study characterising the role of anogenital warts in HIV acquisition among men who have sex with men: a study protocol.

Brandon Brown, Mariam Davtyan, Segundo R Leon, Hugo Sanchez, Gino Calvo, Jeffrey D Klausner, Jerome Galea

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01387412 (The Role of Genital Warts in HIV Acquisition Among MSM in Peru"), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01387412 completednot on this map

The Role of Genital Warts in HIV Acquisition Among MSM in Peru"

TypeobservationalSponsorUniversity of California, Los AngelesRan2012 to 2015Enrolled600ConditionsAnogenital Warts, HIV
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Brandon BrownProgram in Public Health, Department of Population Health and Disease Prevention, University of California, Irvine, California, USA.
Mariam DavtyanProgram in Public Health, Department of Population Health and Disease Prevention, University of California, Irvine, California, USA.
Segundo R LeonUnit of Health, Sexuality and Human Development, Cayetano Heredia University School of Public Health, Lima, Peru.
Hugo SanchezEpicentro Salud, Lima, Peru.
Gino CalvoEpicentro Salud, Lima, Peru.
Jeffrey D KlausnerDivision of Infectious Diseases, Department of Medicine, University of California, Los Angeles, USA.
Jerome GaleaEpicentro Salud, Lima, Peru.
Epicentre (South Africa) · ZAUniversity of California, Irvine · USEsSALUD · PEUniversidad Peruana Cayetano Heredia · PEUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe HIV epidemic in Latin America is concentrated among men who have sex with men (MSM) and transgender women (TGW) with transmission predominately occurring during unprotected anal intercourse. This mode of transmission is also responsible for other sexually transmitted infections (STIs) such as herpes simplex, chlamydia and gonorrhoea, human papillomavirus (HPV)/genital warts and syphilis. Studies assessing the prevalence of HIV and HPV among MSM have not addressed the role of genital warts and HPV-related diseases in the acquisition of HIV infection. Community-based testing programmes are a potentially important way to remove barriers including stigma for individuals to learn about their STI status. METHODS AND ANALYSIS: The prospective cohort study will recruit 600 MSM/TGW at a community centre in Lima, Peru, named Epicentro. Half of the participants will have a history of or have current anogenital warts (AGW), and the other half will have no history of AGW. We will measure the prevalence and acquisition of STIs including syphilis, HPV, chlamydia and gonorrhoea and the HIV-incidence in the two groups. To the best of our knowledge, it will be the first study that specifically examines the impact of genital warts on incident HIV infection. This study will help to understand the relationship between AGW and HIV infection among MSM/TGW in Peru. Furthermore, it may facilitate the development of preventive intervention strategies to reduce the prevalence of AGW and prevent incident HIV infection. HPV-related manifestations may be a good proxy for HIV risk. ETHICS AND DISSEMINATION: This study was approved by institutional review boards at the University of California, Los Angeles (UCLA) in the USA and Impacta in Peru. Study findings will be shared with the Peruvian Ministry of Health as well as other international and national public health organisations. Study results will be translated into Spanish for participants. TRIAL REGISTRATION NUMBER: The Clinicaltrials.gov registration number is NCT01387412.

Indexed as

Homosexuality, MaleTransgender PersonsAdolescentAdultAnus DiseasesCohort StudiesCondylomata AcuminataFemaleHIV InfectionsHumansMaleProspective StudiesYoung Adultgenital wartsHuman papillomavirusmen who have sex with men

Identifiers

PMID25227629
PMCPMC4166134
OpenAlexW2102633894

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.