ArticleBMC plant biology2014
Alfalfa snakin-1 prevents fungal colonization and probably coevolved with rhizobia.
Article in BMC plant biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The Snakin Family of Antimicrobial Peptides: Promising Alternatives to Conventional Antibiotics.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Pangenomic Approach for the Identification and Functional Characterization of Active GASA Antimicrobial Genes in Citrus Rootstocks for Resistance Breeding Against Bacterial Pathogens.Plants (Basel, Switzerland) · 2026Article
- Phosphorus fertilization enhanced overwintering, root system and forage yield of late-seeded alfalfa in sodic soils.Scientific reports · 2024Article
- Genome-Wide Identification and Characterization of Gibberellic Acid-Stimulated Arabidopsis Gene Family in Pineapple (International journal of molecular sciences · 2023Article
- Snakins: antimicrobial potential and prospects of genetic engineering for enhanced disease resistance in plants.Molecular biology reports · 2023Review
- GASA Proteins: Review of Their Functions in Plant Environmental Stress Tolerance.Plants (Basel, Switzerland) · 2023Review
- Article
- Genome-Wide Identification, Evolution, and Expression Analysis of GASA Gene Family inInternational journal of molecular sciences · 2022Article
- Plant-Derived Antimicrobial Peptides: Novel Preservatives for the Food Industry.Foods (Basel, Switzerland) · 2022Review
- Generation of a multi-herbicide-tolerant alfalfa by using base editing.Plant cell reports · 2022Article
- Analysis of CcGASA family members in Citrus clementina (Hort. ex Tan.) by a genome-wide approach.BMC plant biology · 2021Article
- The dissection of R genes and locus Pc5.1 in Phytophthora capsici infection provides a novel view of disease resistance in peppers.BMC genomics · 2021Article
- Expanding the Benefits ofFrontiers in plant science · 2021Article
- Molecular and Biological Properties of Snakins: The Foremost Cysteine-Rich Plant Host Defense Peptides.Journal of fungi (Basel, Switzerland) · 2020Review
- Potato Snakin-1: an antimicrobial player of the trade-off between host defense and development.Plant cell reports · 2020Review
- Biotechnological Perspectives of Omics and Genetic Engineering Methods in Alfalfa.Frontiers in plant science · 2020Review
- Maximizing the expression of transgenic traits into elite alfalfa germplasm using a supertransgene configuration in heterozygous conditions.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- Microevolution Rather than Large Genome Divergence Determines the Effectiveness of Legume-Rhizobia Symbiotic Interaction Under Field Conditions.Journal of molecular evolution · 2017Article
- Over-expression of GmSN1 enhances virus resistance in Arabidopsis and soybean.Plant cell reports · 2017Article
- Minimizing the time and cost of production of transgenic alfalfa libraries using the highly efficient completely sequenced vector pPZP200BAR.Plant cell reports · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe production of antimicrobial peptides is a common defense strategy of living cells against a wide range of pathogens. Plant snakin peptides inhibit bacterial and fungal growth at extremely low concentrations. However, little is known of their molecular and ecological characteristics, including origin, evolutionary equivalence, specific functions and activity against beneficial microbes. The aim of this study was to identify and characterize snakin-1 from alfalfa (MsSN1).
resultsPhylogenetic analysis showed complete congruence between snakin-1 and plant trees. The antimicrobial activity of MsSN1 against bacterial and fungal pathogens of alfalfa was demonstrated in vitro and in vivo. Transgenic alfalfa overexpressing MsSN1 showed increased antimicrobial activity against virulent fungal strains. However, MsSN1 did not affect nitrogen-fixing bacterial strains only when these had an alfalfa origin.
conclusionsThe results reported here suggest that snakin peptides have important and ancestral roles in land plant innate immunity. Our data indicate a coevolutionary process, in which alfalfa exerts a selection pressure for resistance to MsSN1 on rhizobial bacteria. The increased antimicrobial activity against virulent fungal strains without altering the nitrogen-fixing symbiosis observed in MsSN1-overexpressing alfalfa transgenic plants opens the way to the production of effective legume transgenic cultivars for biotic stress resistance.
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