ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2014
Immunomodulatory effects of Ziziphora tenuior L. extract on the dendritic cells.
Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- From Immunization to Autoimmunity: A Deep Dive Into Post-COVID-19 Vaccine Reactions-A Narrative Review.Health science reports · 2026Article
- Deep brain stimulation (DBS) as a therapeutic approach in gait disorders: What does it bring to the table?IBRO neuroscience reports · 2023Review
- N-Acetylcysteine attenuated pulmonary fibrosis induced by bleomycinResearch in pharmaceutical sciences · 2023Article
- Apoptosis Induced by Ziziphora tenuior Essential Oil in Human Colorectal Cancer Cells.BioMed research international · 2021Article
- Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review.Pain research & management · 2018Review
- Kazakh Ziziphora Species as Sources of Bioactive Substances.Molecules (Basel, Switzerland) · 2016Review
- The physiological and pharmacological effects ofAvicenna journal of phytomedicineReview
- Modulation of dendritic cell immune functions by plant components.Journal of microscopy and ultrastructureReview
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundZiziphora tenuior L. (Kakuti in Persian) is used in traditional medicine for treatment of gastrointestinal disorders as carminative and analgesic plant. The other usages of this plant are included treatment of diarrhea and nausea. Therefore in the present study we evaluated the immunomodulatory effects of the ethanolic extract of this plant on the dendritic cells (DCs).
resultsZiziphora tenuior L. extract significantly (p = 0.002) increased the level of surface expression of CD40 as an important co-stimulatory marker on DCs compared to the control. However this extract did not change CD86 and MHC-II molecules, so it could promote DCs phenotypic maturation. Treatment of DCs with the extract resulted in slightly increased of the production of (IL-12); however, this change was not significant. In addition, the ability of treated DCs to stimulate allogenic T cells proliferation and cytokines secretion was examined in the co-cuture of these cells with T cells in mixed lymphocyte reaction (MLR). Z. tenuior L. at the 100 μg/ml concentration inhibited the proliferation of allogenic T cells and also significantly (P < 0.001) increased the level of IL-10. Moreover, the extract at 10-100 μg/ml concentration caused slightly increase in IFN-γ production and decreased IL-4 cytokines but these changes were not significant.
conclusionsThese findings indicated that Z. tenuior L. extract can modulate immune response by induction of CD40 expression on DCs and cytokine production; whereas it can inhibit T cell stimulating activity of DCs in high concentration. These findings possibly in part explain the traditional use of this plant in treatment of immune-mediated disorders. However future studies are needed.
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