Evidence map›Paper›PMID 25227407›Full record

ArticleJournal of the American Heart Association2014

Left ventricular diameter and risk stratification for sudden cardiac death.

Kumar Narayanan, Kyndaron Reinier, Carmen Teodorescu, Audrey Uy-Evanado, Ryan Aleong, Harpriya Chugh, Gregory A Nichols, Karen Gunson, Barry London, Jonathan Jui and 1 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 3 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 3 syntheses or guidelines pooled it, 118 citations in OpenAlex.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Kumar NarayananCedars Sinai Medical Center, Los Angeles, CA (K.N., K.R., C.T., A.U.E., H.C., S.S.C.).
Kyndaron ReinierCedars Sinai Medical Center, Los Angeles, CA (K.N., K.R., C.T., A.U.E., H.C., S.S.C.).
Carmen TeodorescuCedars Sinai Medical Center, Los Angeles, CA (K.N., K.R., C.T., A.U.E., H.C., S.S.C.).
Audrey Uy-EvanadoCedars Sinai Medical Center, Los Angeles, CA (K.N., K.R., C.T., A.U.E., H.C., S.S.C.).
Ryan AleongUniversity of Colorado, Denver, CO (R.A.).
Harpriya ChughCedars Sinai Medical Center, Los Angeles, CA (K.N., K.R., C.T., A.U.E., H.C., S.S.C.).
Gregory A NicholsKaiser Permanente, Portland, OR (G.A.N.).
Karen GunsonOregon Health and Science University, Portland, OR (K.G., J.J.).
Barry LondonUniversity of Iowa, Iowa City, IA (B.L.).
Jonathan JuiOregon Health and Science University, Portland, OR (K.G., J.J.).
Sumeet S ChughCedars Sinai Medical Center, Los Angeles, CA (K.N., K.R., C.T., A.U.E., H.C., S.S.C.).
Cedars-Sinai Medical Center · USOregon Health & Science University · USKaiser Permanente Center for Health Research · USUniversity of Colorado Denver · USUniversity of Iowa · US

Funding

Determinants of Sudden Death Risk with Left Ventricular HypertrophyR01HL088416 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI CHUGH, SUMEET S. · 2007 to 2011
$2.4M
Prolonged Ventricular Depolarization and Sudden Death in the CommunityR01HL105170 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHUGH, SUMEET S. · 2010 to 2013
$1.6M
NHLBI NIH HHS HL105170NHLBI NIH HHS R01 HL088416NHLBI NIH HHS R01HL088416NHLBI NIH HHS R01 HL105170
6 · The paper itself

Abstract

backgroundLeft ventricular (LV) diameter is routinely measured on the echocardiogram but has not been jointly evaluated with the ejection fraction (EF) for risk stratification of sudden cardiac death (SCD). METHODS AND

resultsFrom a large ongoing community-based study of SCD (The Oregon Sudden Unexpected Death Study; population ≈1 million), SCD cases were compared with geographic controls. LVEF and LV diameter, measured using the LV internal dimension in diastole (categorized as normal, mild, moderate, or severe dilatation using American Society of Echocardiography definitions) were assessed from echocardiograms prior but unrelated to the SCD event. Cases (n=418; 69.5±13.8 years), compared with controls (n=329; 67.7±11.9 years), more commonly had severe LV dysfunction (EF ≤35%; 30.5% versus 18.8%; P<0.01) and larger LV diameter (52.2±10.5 mm versus 49.7±7.9 mm; P<0.01). Moderate or severe LV dilatation (16.3% versus 8.2%; P=0.001) and severe LV dilatation (8.1% versus 2.1%; P<0.001) were significantly more frequent in cases. In multivariable analysis, severe LV dilatation was an independent predictor of SCD (odds ratio 2.5 [95% CI 1.03 to 5.9]; P=0.04). In addition, subjects with both EF ≤35% and severe LV dilatation had higher odds for SCD compared with those with low EF only (odds ratio 3.8 [95% CI 1.5 to 10.2] for both versus 1.7 [95% CI 1.2 to 2.5] for low EF only), suggesting that severe LV dilatation additively increased SCD risk.

conclusionLV diameter may contribute to risk stratification for SCD independent of the LVEF. This readily available echocardiographic measure warrants further prospective evaluation.

Indexed as

AgedAged, 80 and overAge DistributionCase-Control StudiesCause of DeathDeath, Sudden, CardiacEchocardiography, DopplerFemaleFollow-Up StudiesHeart VentriclesHumansMaleMiddle AgedReference ValuesRetrospective StudiesRisk Assessmentejection fractionLV diameterrisk stratificationsudden cardiac death

Identifiers

PMID25227407
PMCPMC4323796
OpenAlexW2120437701

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.