Evidence map›Paper›PMID 25227406›Full record

ArticleJournal of the American Heart Association2014

Population attributable risks of hypertension and diabetes for cardiovascular disease and stroke in the northern Manhattan study.

Joshua Z Willey, Yeseon Park Moon, Emily Kahn, Carlos J Rodriguez, Tatjana Rundek, Ken Cheung, Ralph L Sacco, Mitchell S V Elkind

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.

  1. Effect of alcohol on blood pressure.The Cochrane database of systematic reviews · 2020
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  16. Transient ischemic attack and minor stroke: diagnosis, risk stratification and management.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Joshua Z WilleyDepartment of Neurology, Columbia University, New York, USA (J.Z.W., Y.P.M., E.K., M.V.E.).
Yeseon Park MoonDepartment of Neurology, Columbia University, New York, USA (J.Z.W., Y.P.M., E.K., M.V.E.).
Emily KahnDepartment of Neurology, Columbia University, New York, USA (J.Z.W., Y.P.M., E.K., M.V.E.).
Carlos J RodriguezDepartment of Medicine, Wake Forest University, Winston-Salem, NC, USA (C.J.R.).
Tatjana RundekDepartment of Neurology, University of Miami, Miami, FL, USA (T.R., R.L.S.).
Ken CheungDepartment of Biostatistics, Columbia University, New York, USA (K.C.).
Ralph L SaccoDepartment of Neurology, University of Miami, Miami, FL, USA (T.R., R.L.S.).
Mitchell S V ElkindDepartment of Neurology, Columbia University, New York, USA (J.Z.W., Y.P.M., E.K., M.V.E.) Department of Epidemiology, Columbia University, New York, USA (M.V.E.).
Columbia University · USUniversity of Miami · USWake Forest University · US

Funding

Stroke Incidence and Risk Factors in a Tri-Ethnic RegionR37NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 2008 to 2014
$12.1M
Epidemiologic Determinants of Change in Cardiac Structure and Function (ECHO-SOL 2)R01HL104199 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RODRIGUEZ, CARLOS JOSE · 2011 to 2018
$5.3M
Neuro-vascular Disease as a Cause of Impaired MobilityK23NS073104 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WILLEY, JOSHUA ZEBADIAH · 2011 to 2015
$940k
NHLBI NIH HHS R01 HL104199NINDS NIH HHS K23 NS 073104NINDS NIH HHS K23 NS073104NINDS NIH HHS R37 NS029993NINDS NIH HHS R37 NS 29993
6 · The paper itself

Abstract

backgroundUnderstanding the population-level risk factor contribution to disease incidence is critical for effective allocation of resources for prevention. There are little data on the contribution of cardiovascular disease (CVD) risk factors in multiethnic elderly populations. METHODS AND

resultsThe Northern Manhattan Study (n=3298) is a population-based prospective cohort study of CVD outcomes in a multiethnic urban population. Multivariable Cox's models were used to calculate hazard ratios, population attributable risk (PAR), and 95% confidence intervals (CIs) for (1) combined vascular event (VE) endpoint of stroke/myocardial infarction/vascular death (n=835) and (2) stroke (n=347). The PAR resulting from hypertension (HTN) was 24.3% (95% CI, 13.2 to 35.4) for VE and 29.9% (95% CI, 12.5 to 47.4) for stroke; PAR resulting from diabetes was 12.7% (95% CI, 8.2 to 17.2) for VE and 19.5% (95% CI, 12.4 to 26.5) for stroke. The PAR resulting from HTN and diabetes for stroke differed by race-ethnicity and age (P for differences <0.05). PAR for stroke reslting from HTN was greater among Hispanics (50.6%; 95% CI, 29.2 to 71.9) than non-Hispanic whites (2.6%; 95% CI, -33.2 to 38.6) and in those <80 years of age (35.6%; 95% CI, 18.9 to 52.3) than in those ≥80 (-0.3%; 95% CI, -34.2 to 33.6). Similarly, the PAR for stroke resulting from diabetes was 23.6% among those <80 years of age (95% CI, 15.7 to 31.5) and 2.3% among those ≥80 (95% CI, -8.2 to 12.7; P for difference=0.001). The PAR for VE did not differ by age/sex/race-ethnicity.

conclusionsHTN and diabetes have important effects on the burden of stroke, particularly among those younger than age 80 and Hispanics. Public health campaigns targeted at specific risk factors in specific populations can lead to a greater reduction in CVD.

Indexed as

Health Status DisparitiesAgedAged, 80 and overAge FactorsCardiovascular DiseasesCohort StudiesDiabetes Mellitus, Type 2EthnicityFemaleHumansHypertensionIncidenceMaleMiddle AgedMultivariate AnalysisNeeds AssessmentAgingattributable riskdiabeteshypertensionstrokevascular death

Identifiers

PMID25227406
PMCPMC4323833
OpenAlexW2137320069

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.