ArticleCellular and molecular life sciences : CMLS2015
Prion strains are differentially released through the exosomal pathway.
Article in Cellular and molecular life sciences : CMLS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Exosomes in Amyloid Propagation-Roles in Neurodegeneration.Molecular neurobiology · 2026Review
- The structural line between prion and "prion-like": Insights from prion protein and tau.Current opinion in neurobiology · 2024Review
- Contribution of Extracellular Vesicles and Molecular Chaperones in Age-Related Neurodegenerative Disorders of the CNS.International journal of molecular sciences · 2023Review
- Propagation and Dissemination Strategies of Transmissible Spongiform Encephalopathy Agents in Mammalian Cells.International journal of molecular sciences · 2022Review
- The Role of Extracellular Vesicles in Systemic Lupus Erythematosus.Frontiers in cell and developmental biology · 2022Review
- Mesenchymal Stem Cell-Derived Extracellular Vesicles Therapy for Pulmonary Hypertension: A Comprehensive Review of Preclinical Studies.Journal of interventional cardiology · 2022Review
- Cerebrospinal Fluid and Plasma Small Extracellular Vesicles and miRNAs as Biomarkers for Prion Diseases.International journal of molecular sciences · 2021Article
- From Cell Culture to Organoids-Model Systems for Investigating Prion Strain Characteristics.Biomolecules · 2021Review
- Assessing extracellular vesicles from bovine mammary gland epithelial cells cultured in FBS-free medium.Extracellular vesicles and circulating nucleic acids · 2021Article
- Circulating Exosomal miRNA as Diagnostic Biomarkers of Neurodegenerative Diseases.Frontiers in molecular neuroscience · 2020Review
- CNS-Derived Blood Exosomes as a Promising Source of Biomarkers: Opportunities and Challenges.Frontiers in molecular neuroscience · 2020Review
- Targetting Exosomes as a New Biomarker and Therapeutic Approach for Alzheimer's Disease.Clinical interventions in aging · 2020Review
- Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids.Acta neuropathologica communications · 2019Article
- Environmental neurotoxicant-induced dopaminergic neurodegeneration: a potential link to impaired neuroinflammatory mechanisms.Pharmacology & therapeutics · 2019Review
- Cellular and Molecular Mechanisms of Prion Disease.Annual review of pathology · 2019Review
- Specialized Intercellular Communications via Cytonemes and Nanotubes.Annual review of cell and developmental biology · 2018Review
- Cellular mechanisms responsible for cell-to-cell spreading of prions.Cellular and molecular life sciences : CMLS · 2018Review
- How do PrPPathogens (Basel, Switzerland) · 2017Review
- The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases.The Journal of cell biology · 2017Review
- Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-to-cell transfer of prions is a crucial step in the spreading of prion infection through infected tissue. At the cellular level, several distinct pathways including direct cell-cell contacts and release of various types of infectious extracellular vesicles have been described that may potentially lead to infection of naïve cells. The relative contribution of these pathways and whether they may vary depending on the prion strain and/or on the infected cell type are not yet known. In this study we used a single cell type (RK13) infected with three different prion strains. We showed that in each case, most of the extracellular prions resulted from active cell secretion through the exosomal pathway. Further, quantitative analysis of secreted infectivity indicated that the proportion of prions eventually secreted was dramatically dependent on the prion strain. Our data also highlight that infectious exosomes secreted from cultured cells might represent a biologically pertinent material for spiking experiments. Also discussed is the appealing possibility that abnormal PrP from different prion strains may differentially interact with the cellular machinery to promote secretion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.