ReviewBirth defects research. Part C, Embryo today : reviews2014
Cranial neural crest cell contribution to craniofacial formation, pathology, and future directions in tissue engineering.
Review in Birth defects research. Part C, Embryo today : reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Unveiling the Prevalence and Surgical Burden of Neurocristopathies: A Scoping Review and Statistical Analysis.Research square · 2026Article
- Non-Syndromic or Anomaly-Associated Genes (MYH3, GREM1, IRF6) and Their Proteins in Unilateral Right Cleft Tissue.International journal of molecular sciences · 2026Article
- Exploring the association between SNPs and facial morphology in a Spanish population.Scientific reports · 2025Article
- Article
- Congenital Zika Virus Syndrome: Microcephaly and Orofacial Anomalies.Life (Basel, Switzerland) · 2023Review
- Connecting the dots: Melanoma cell of origin, tumor cell plasticity, trans-differentiation, and drug resistance.Pigment cell & melanoma research · 2023Review
- An analysis of lateralized neural crest marker expression across development in the Mexican tetra,Frontiers in cell and developmental biology · 2023Article
- Inhibition of Cyclooxygenase-2 Alters Craniofacial Patterning during Early Embryonic Development of Chick.Journal of developmental biology · 2021Article
- Predifferentiated Gingival Stem Cell-Induced Bone Regeneration in Rat Alveolar Bone Defect Model.Tissue engineering. Part A · 2021Article
- SPECC1L regulates palate development downstream of IRF6.Human molecular genetics · 2020Article
- Anterior segment dysgenesis and secondary glaucoma in Goldenhar syndrome.Indian journal of ophthalmology · 2019Article
- Neural crest stem cells from human epidermis of aged donors maintain their multipotency in vitro and in vivo.Scientific reports · 2019Article
- Pathological ASXL1 Mutations and Protein Variants Impair Neural Crest Development.Stem cell reports · 2019Article
- Tissue Preparation and Immunostaining of Mouse Craniofacial Tissues and Undecalcified Bone.Journal of visualized experiments : JoVE · 2019Article
- Derivation of neural crest stem cells from human epidermal keratinocytes requires FGF-2, IGF-1, and inhibition of TGF-β1.Bioengineering & translational medicine · 2018Article
- Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage.eLife · 2018Article
- Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- BmpR1A is a major type 1 BMP receptor for BMP-Smad signaling during skull development.Developmental biology · 2017Article
- Genetic advances in craniosynostosis.American journal of medical genetics. Part A · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
This review provides an overview of the state and future directions of development and pathology in the craniofacial complex in the context of Cranial Neural Crest Cells (CNCC). CNCC are a multipotent cell population that is largely responsible for forming the vertebrate head. We focus on findings that have increased the knowledge of gene regulatory networks and molecular mechanisms governing CNCC migration and the participation of these cells in tissue formation. Pathology due to aberrant migration or cell death of CNCC, termed neurocristopathies, is discussed in addition to craniosynostoses. Finally, we discuss tissue engineering applications that take advantage of recent advancements in genome editing and the multipotent nature of CNCC. These applications have relevance to treating diseases due directly to the failure of CNCC, and also in restoring tissues lost due to a variety of reasons.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.