Evidence map›Paper›PMID 25227126›Full record

ArticleNeuro-oncology2015

Relationships between tumor grade and neurocognitive functioning in patients with glioma of the left temporal lobe prior to surgical resection.

Kyle R Noll, Catherine Sullaway, Mateo Ziu, Jeffrey S Weinberg, Jeffrey S Wefel

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 4 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 4 syntheses or guidelines pooled it, 152 citations in OpenAlex.

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  15. Early region-specific impact of adjuvant radiation therapy on cognition and quality of life in adult patients with primary brain tumors.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kyle R NollDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (K.R.N., C.S., J.S. Wefel); Brain and Spine Institute, Seton Hospital, Austin, Texas (M.Z.); Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas (J.S. Weinberg).
Catherine SullawayDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (K.R.N., C.S., J.S. Wefel); Brain and Spine Institute, Seton Hospital, Austin, Texas (M.Z.); Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas (J.S. Weinberg).
Mateo ZiuDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (K.R.N., C.S., J.S. Wefel); Brain and Spine Institute, Seton Hospital, Austin, Texas (M.Z.); Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas (J.S. Weinberg).
Jeffrey S WeinbergDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (K.R.N., C.S., J.S. Wefel); Brain and Spine Institute, Seton Hospital, Austin, Texas (M.Z.); Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas (J.S. Weinberg).
Jeffrey S WefelDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (K.R.N., C.S., J.S. Wefel); Brain and Spine Institute, Seton Hospital, Austin, Texas (M.Z.); Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas (J.S. Weinberg).
Seton Medical Center · USThe University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Multimodal MRI Biomarker of Mild Cognitive Impairment in Breast CancerR01NR014195 · NINR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KESLER, SHELLI R, WEFEL, JEFFREY SCOTT · 2012 to 2017
$2.5M
NCI NIH HHS P30 CA016672NINR NIH HHS R01 NR014195NINR NIH HHS R01NR014195
6 · The paper itself

Abstract

backgroundVarious tumor characteristics have been associated with neurocognitive functioning (NCF), though the role of tumor grade has not been adequately examined.

methodsSeventy-two patients with histologically confirmed grade IV glioma (n = 37), grade III glioma (n = 20), and grade II glioma (n = 15) in the left temporal lobe completed preoperative neuropsychological assessment. Rates of impairment and mean test performances were compared by tumor grade with follow-up analysis of the influence of other tumor- and patient-related characteristics on NCF.

resultsNCF impairment was more frequent in patients with grade IV tumor compared with patients with lower-grade tumors in verbal learning, executive functioning, as well as language abilities. Mean performances significantly differed by tumor grade on measures of verbal learning, processing speed, executive functioning, and language, with the grade IV group exhibiting worse performances than patients with lower-grade tumors. Group differences in mean performances remained significant when controlling for T1-weighted and fluid attenuated inversion recovery MRI-based lesion volume. Performances did not differ by seizure status or antiepileptic and steroid use.

conclusionsCompared with patients with grade II or III left temporal lobe glioma, patients with grade IV tumors exhibit greater difficulty with verbal learning, processing speed, executive functioning, and language. Differences in NCF associated with glioma grade were independent of lesion volume, seizure status, and antiepileptic or steroid use, lending support to the concept of "lesion momentum" as a primary contributor to deficits in NCF of newly diagnosed patients prior to surgery.

Indexed as

AdolescentAdultAgedAttentionBrain NeoplasmsExecutive FunctionFemaleGliomaHumansLearningMaleMiddle AgedNeoplasm StagingNeuropsychological TestsTemporal LobeYoung Adultbrain tumorcognitiongliomahistopathologyneuropsychology

Identifiers

PMID25227126
PMCPMC4483071
OpenAlexW1989474634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.