Evidence map›Paper›PMID 25226797›Full record

ReviewMedicine and sport science2014

Sedentary behavior as a mediator of type 2 diabetes.

Marc T Hamilton, Deborah G Hamilton, Theodore W Zderic

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Medicine and sport science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  7. Intradialytic Exercise: Effects on Arterial Stiffness and Gait Speed in Patients Undergoing Hemodialysis.Medical science monitor : international medical journal of experimental and clinical research · 2025
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marc T HamiltonPennington Biomedical Research Center, Baton Rouge, La., USA.
Deborah G Hamilton
Theodore W Zderic

Funding

Vascular Biology: Exercise Training and Vascular DiseaseP01HL052490 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI BOWLES, DOUGLAS K · 1995 to 2010
$19.3M
RUNNING INDUCED INCREASE IN MUSCLE LPL MRNAR01HL057367 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HAMILTON, MARC T · 1997 to 2000
$201k
Lipids and gene regulation in skeletal muscleF32HL070482 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI ZDERIC, THEODORE W · 2002 to 2004
$125k
EXERCISE INDUCED INCREASE IN MUSCLE LIPOPROTEIN LIPASEF32AR008455 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HAMILTON, MARC T · 1996 to 1998
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NHLBI NIH HHS F32 HL070482NHLBI NIH HHS HL52490NHLBI NIH HHS HL57367NHLBI NIH HHS HL70482NHLBI NIH HHS P01 HL052490NIAMS NIH HHS F32 AR008455PHS HHS 00119611
6 · The paper itself

Abstract

Over the past 5 years, the fastest growing new area of physical activity research centered around the concept that the large amount of time people spend sitting inactive may have significant physiological consequences hazardous to human health, including risk for type 2 diabetes and poor metabolism of lipids and glucose. Meta-analysis (10 studies) suggests there is a 112% greater relative risk associated with a large duration of sedentary behavior for type 2 diabetes. Meta-analysis also indicates significantly greater odds for metabolic syndrome. We also summarize results for 7 studies using objective measures of total sedentary time and focusing on cardiometabolic risks in persons at high risk for type 2 diabetes or already diagnosed with type 2 diabetes. The underlying hypothesis introduced in 2004 by the inactivity physiology paradigm has been that frequent and abundant contractile activity by certain types of skeletal muscle can have a potent influence on key physiological processes, even when the intensity is below that achieved through exercise. We explain some of the mechanisms for why the metabolism in slow-twitch oxidative skeletal muscle is key for understanding the healthy responses to low-intensity physical activity (LIPA). Findings from objective measures from inclinometry indicated that the quartile range for weekly sedentary time is ∼29 h/week. The total daily time that people sit, stand, and accumulate nonexercise steps is independent of traditionally recommended moderate-vigorous physical activity. The large amount of sedentary time associated with risk for disease can only be reduced significantly with safe and nonfatiguing LIPA, especially in the most at-risk proportion of the population. Importantly, experimental studies are starting to indicate that it will be especially insightful to understand the acute dose-response effects of LIPA in order to understand why reducing sedentary time can improve lipid and glucose metabolism for the prevention and treatment of chronic disorders related to type 2 diabetes.

Indexed as

Sedentary BehaviorActigraphyAnimalsDiabetes Mellitus, Type 2GlucoseHumansLipid MetabolismMetabolic SyndromeMotor ActivityMuscle, SkeletalRisk FactorsTime FactorsGlucose

Identifiers

PMID25226797
PMCPMC4364419

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.