Evidence map›Paper›PMID 25226587›Full record

ArticlePloS one2014

A comparison of micro-CT and dental CT in assessing cortical bone morphology and trabecular bone microarchitecture.

Jui-Ting Hsu, Ying-Ju Chen, Jung-Ting Ho, Heng-Li Huang, Shun-Ping Wang, Fu-Chou Cheng, Jay Wu, Ming-Tzu Tsai

Abstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jui-Ting HsuSchool of Dentistry, College of Medicine, China Medical University, Taichung, Taiwan.
Ying-Ju ChenStem Cell Medical Research Center, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Jung-Ting HoSchool of Dentistry, College of Medicine, China Medical University, Taichung, Taiwan.
Heng-Li HuangSchool of Dentistry, College of Medicine, China Medical University, Taichung, Taiwan.
Shun-Ping WangDepartment of Orthopaedics, Taichung Veterans General Hospital, Taichung, Taiwan.
Fu-Chou ChengStem Cell Medical Research Center, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Jay WuDepartment of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.
Ming-Tzu TsaiDepartment of Biomedical Engineering, Hungkuang University, Taichung, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study was to evaluate the relationship between the trabecular bone microarchitecture and cortical bone morphology by using micro-computed tomography (micro-CT) and dental cone-beam computed tomography (dental CT). MATERIALS AND

methodsSixteen femurs and eight fifth lumbar vertebrae were collected from eight male Sprague Dawley rats. Four trabecular bone microarchitecture parameters related to the fifth lumbar vertebral body (percent bone volume [BV/TV], trabecular thickness [TbTh], trabecular separation [TbSp], and trabecular number [TbN]) were calculated using micro-CT. In addition, the volumetric cancellous bone grayscale value (vCanGrayscale) of the fifth lumbar vertebral body was measured using dental CT. Furthermore, four cortical bone morphology parameters of the femoral diaphysis (total cross-sectional area [TtAr], cortical area [CtAr], cortical bone area fraction [CtAr/TtAr], and cortical thickness [CtTh]) were calculated using both micro-CT and dental CT. Pearson analysis was conducted to calculate the correlation coefficients (r) of the micro-CT and dental CT measurements. Paired-sample t tests were used to compare the differences between the measurements of the four cortical bone morphology parameters obtained using micro-CT and dental CT.

resultsHigh correlations between the vCanGrayscale measured using dental CT and the trabecular bone microarchitecture parameters (BV/TV [r = 0.84] and TbTh [r = 0.84]) measured using micro-CT were observed. The absolute value of the four cortical bone morphology parameters may be different between the dental CT and micro-CT approaches. However, high correlations (r ranged from 0.71 to 0.90) among these four cortical bone morphology parameters measured using the two approaches were obtained.

conclusionWe observed high correlations between the vCanGrayscale measured using dental CT and the trabecular bone microarchitecture parameters (BV/TV and TbTh) measured using micro-CT, in addition to high correlations between the cortical bone morphology measured using micro-CT and dental CT. Further experiments are necessary to validate the use of dental CT on human bone.

Indexed as

Cone-Beam Computed TomographyX-Ray MicrotomographyAnimalsBone and BonesBone DensityFemurImage Processing, Computer-AssistedImaging, Three-DimensionalMaleRats

Identifiers

PMID25226587
PMCPMC4166457

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.