Evidence map›Paper›PMID 25226553›Full record

ArticleTranslational psychiatry2014

Serotonin transporter [corrected] methylation and response to cognitive behaviour therapy in children with anxiety disorders.

S Roberts, K J Lester, J L Hudson, R M Rapee, C Creswell, P J Cooper, K J Thirlwall, J R I Coleman, G Breen, C C Y Wong and 1 more

Erratum issued 2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03062891 nacompletednot on this mapstarted 2016, after this paper: background citation

Sleep Treatment Outcome Predictors: A Pilot Study (STOP-pilot)

TypeinterventionalSponsorKing's College LondonRan2016 to 2017Enrolled240ConditionsSleep ProblemArmsOnline CBT for insomnia
NCT04029740 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Searching for Exosomal microRNAs and Cellular Biomarkers and Mechanisms Underlying the Differences Between Panic Disorder Patients Who Are Responders and Non-responders to Cognitive Behavior Therapy

TypeinterventionalSponsorHebrew University of JerusalemRan2019 to 2021Enrolled80ConditionsPanic DisorderArmsCBT- both internet and face to face, No intervention
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.

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  4. Epigenetic markers of response to psychotherapy in obsessive-compulsive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

S RobertsMRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London UK.
K J LesterMRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London UK.
J L HudsonCentre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia.
R M RapeeCentre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia.
C CreswellWinnicott Research Unit, School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.
P J Cooper1] Winnicott Research Unit, School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK [2] Department of Psychology, Stellenbosch University, Western Cape, South Africa.
K J ThirlwallWinnicott Research Unit, School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.
J R I ColemanMRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London UK.
G BreenMRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London UK.
C C Y WongMRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London UK.
T C EleyMRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London UK.
King's College London · GBUniversity of Reading · GBMacquarie University · AU

Funding

Department of Health PB-PG-0107-12042Department of Health PB-PG-0110-21190Department of Health RP_2014-04-018Medical Research Council G0601020Medical Research Council G0601874Medical Research Council G0802326Medical Research Council G0901874Medical Research Council G0901874/1Medical Research Council MR/J011762/1Medical Research Council TG09-800-17
6 · The paper itself

Abstract

Anxiety disorders that are the most commonly occurring psychiatric disorders in childhood, are associated with a range of social and educational impairments and often continue into adulthood. Cognitive behaviour therapy (CBT) is an effective treatment option for the majority of cases, although up to 35-45% of children do not achieve remission. Recent research suggests that some genetic variants may be associated with a more beneficial response to psychological therapy. Epigenetic mechanisms such as DNA methylation work at the interface between genetic and environmental influences. Furthermore, epigenetic alterations at the serotonin transporter (SERT) promoter region have been associated with environmental influences such as stressful life experiences. In this study, we measured DNA methylation upstream of SERT in 116 children with an anxiety disorder, before and after receiving CBT. Change during treatment in percentage DNA methylation was significantly different in treatment responders vs nonresponders. This effect was driven by one CpG site in particular, at which responders increased in methylation, whereas nonresponders showed a decrease in DNA methylation. This is the first study to demonstrate differences in SERT methylation change in association with response to a purely psychological therapy. These findings confirm that biological changes occur alongside changes in symptomatology following a psychological therapy such as CBT.

Indexed as

Cognitive Behavioral TherapyAdolescentAnxiety DisordersChildDNA MethylationFemaleHumansMaleSerotonin Plasma Membrane Transport ProteinsTreatment OutcomeSerotonin Plasma Membrane Transport Proteins

Identifiers

PMID25226553
PMCPMC4203012
OpenAlexW2084286303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.