ArticlePloS one2014
Nasal continuous positive airway pressure inhibits gastroesophageal reflux in newborn lambs.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Hypoxemia Surrounding Enteral Feeds in Preterm Infants Receiving Extended Continuous Positive Airway Pressure.Research square · 2026Article
- Effects of Nasal Respiratory Support on Laryngeal and Esophageal Reflexes in Preterm Lambs.Pediatric research · 2024Article
- Differentiating esophageal sensitivity phenotypes using pH-impedance in intensive care unit infants referred for gastroesophageal reflux symptoms.Pediatric research · 2021Article
- Effects of upper airway obstruction or hypoxia on gastroesophageal reflux in newborn lambs.Pediatric research · 2021Article
- Effect of nasal noninvasive respiratory support methods on pharyngeal provocation-induced aerodigestive reflexes in infants.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Inhibitory Effect of Nasal Intermittent Positive Pressure Ventilation on Gastroesophageal Reflux.PloS one · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUsing esophageal pHmetry, nasal CPAP (nCPAP) has been shown to decrease acid gastroesophageal reflux (GER) in adult humans. Although both GER (mainly non-acid) and nCPAP use are very frequent in newborns, the effect of nCPAP on GER in early life is unknown. Having recently shown that the newborn lamb is a unique model for studying neonatal GER, our main objective was to assess the effect of nCPAP on GER in newborn lambs.
methodsEight newborn lambs, aged 2-3 days, were studied. Continuous esophageal pH-Impedance monitoring and polysomnography were performed for six hours during both spontaneous breathing and nCPAP application at 6 cmH2O (nCPAP(6)), in a randomized order. Results were compared in the two experimental conditions, as well as without CPAP during the following 6 hours.
resultsi) nCPAP(6) virtually abolished GER [mean ± SD reflux number for 6 h = 9.1 ± 8.6 without nCPAP(6) vs. 0.6 ± 1 with nCPAP(6), P<0.05]; ii) GER number was also reduced during the 6 h-period following nCPAP(6) application (18 ± 16 without nCPAP(6) vs. 7 ± 8.1 with nCPAP(6), P<0.05); iii) nCPAP(6) decreased the depth and duration of lower esophageal sphincter relaxation.
conclusionsnCPAP inhibits GER in the newborn lamb. Further clinical studies using different levels of nasal CPAP are needed to confirm this result in human infants.
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