ArticlePLoS biology2014
Disentangling human tolerance and resistance against HIV.
Article in PLoS biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 79 citations in OpenAlex.
- A Comparative Analysis of Aging Across Causes of Death.Evolutionary applications · 2026Article
- Deciphering host-virus interaction networks in ALV infection: an integrative multi-omics perspective.Frontiers in immunology · 2026Review
- Pathogen-induced damage in Drosophila: Uncoupling disease tolerance from resistance.PLoS pathogens · 2025Article
- Reconciling founder variant multiplicity of HIV-1 infection with the rate of CD4Journal of the Royal Society, Interface · 2024Article
- Female reproductive tract microbiota varies with MHC profile.Proceedings. Biological sciences · 2024Article
- Coevolution of Age-Structured Tolerance and Virulence.Bulletin of mathematical biology · 2024Article
- Article
- Per-pathogen virulence of HIV-1 subtypes A, C and D.Proceedings. Biological sciences · 2023Article
- Virulence decomposition for bifurcating infections.Proceedings. Biological sciences · 2023Article
- The Role of Punicalagin and Its Metabolites in Atherosclerosis and Risk Factors Associated with the Disease.International journal of molecular sciences · 2023Review
- Intraspecific genetic variation in host vigour, viral load and disease tolerance during Drosophila C virus infection.Open biology · 2023Article
- Mechanisms of damage prevention, signalling and repair impact disease tolerance.Proceedings. Biological sciences · 2022Article
- Decomposing virulence to understand bacterial clearance in persistent infections.Nature communications · 2022Article
- Transmitted HIV-1 is more virulent in heterosexual individuals than men-who-have-sex-with-men.PLoS pathogens · 2022Article
- It's a hard knock life for some: Heterogeneity in infection life history of salmonids influences parasite disease outcomes.The Journal of animal ecology · 2021Article
- Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm.eLife · 2021Review
- The within-host fitness of HIV-1 increases with age in ART-naïve HIV-1 subtype C infected children.Scientific reports · 2021Article
- Proliferation and benevolence-A framework for dissecting the mechanisms of microbial virulence and health promotion.Evolutionary applications · 2020Article
- Disentangling bacterial invasiveness from lethality in an experimental host-pathogen system.Molecular systems biology · 2019Article
- Specific MHC class I supertype associated with parasite infection and color morph in a wild lizard population.Ecology and evolution · 2018Article
Corrections and comments
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Authors and funding
11 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In ecology, "disease tolerance" is defined as an evolutionary strategy of hosts against pathogens, characterized by reduced or absent pathogenesis despite high pathogen load. To our knowledge, tolerance has to date not been quantified and disentangled from host resistance to disease in any clinically relevant human infection. Using data from the Swiss HIV Cohort Study, we investigated if there is variation in tolerance to HIV in humans and if this variation is associated with polymorphisms in the human genome. In particular, we tested for associations between tolerance and alleles of the Human Leukocyte Antigen (HLA) genes, the CC chemokine receptor 5 (CCR5), the age at which individuals were infected, and their sex. We found that HLA-B alleles associated with better HIV control do not confer tolerance. The slower disease progression associated with these alleles can be fully attributed to the extent of viral load reduction in carriers. However, we observed that tolerance significantly varies across HLA-B genotypes with a relative standard deviation of 34%. Furthermore, we found that HLA-B homozygotes are less tolerant than heterozygotes. Lastly, tolerance was observed to decrease with age, resulting in a 1.7-fold difference in disease progression between 20 and 60-y-old individuals with the same viral load. Thus, disease tolerance is a feature of infection with HIV, and the identification of the mechanisms involved may pave the way to a better understanding of pathogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.