ArticleThe ISME journal2014
Comparative genomics reveals surprising divergence of two closely related strains of uncultivated UCYN-A cyanobacteria.
Article in The ISME journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 96 citations in OpenAlex.
- Diel remodeling and cellular integration of the nitroplast.bioRxiv : the preprint server for biology · 2026Article
- Genomes of nitrogen-fixing eukaryotes reveal an alternate path for organellogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Comparative Genomics Insights Into the Evolutionary Disparities Between Nitroplast-Evolved Ecotype UCYN-A2 and Its Closest Relative UCYN-A1.Ecology and evolution · 2025Article
- Protein import into bacterial endosymbionts and evolving organelles.The FEBS journal · 2025Review
- Biotechnological Applications of Cyanobacteria: Synechocystis and Synechococcus Strains.Advances in biochemical engineering/biotechnology · 2025Review
- Exploring Sustainable Agriculture with Nitrogen-Fixing Cyanobacteria and Nanotechnology.Molecules (Basel, Switzerland) · 2024Review
- Protein NirP1 regulates nitrite reductase and nitrite excretion in cyanobacteria.Nature communications · 2024Article
- Isolation and biogeography of the oligotrophic ocean diazotroph, Crocosphaera waterburyi nov. sp.The ISME journal · 2024Article
- Metagenomics reveals the genetic diversity between sublineages of UCYN-A and their algal host plastids.ISME communications · 2024Article
- Microevolutionary patterns in ecotypes of the symbiotic cyanobacterium UCYN-A revealed from a Northwest Atlantic coastal time series.Science advances · 2023Article
- Distribution and survival strategies of endemic and cosmopolitan diazotrophs in the Arctic Ocean.The ISME journal · 2023Article
- Symbiotic UCYN-A strains co-occurred with El Niño, relaxed upwelling, and varied eukaryotes over 10 years off Southern California.ISME communications · 2023Article
- Open ocean and coastal strains of the N2-fixing cyanobacterium UCYN-A have distinct transcriptomes.PloS one · 2023Article
- Primer design for the amplification of the ammonium transporter genes from the uncultured haptophyte algal species symbiotic with the marine nitrogen-fixing cyanobacterium UCYN-A1.Frontiers in microbiology · 2023Article
- Elucidation of trophic interactions in an unusual single-cell nitrogen-fixing symbiosis using metabolic modeling.PLoS computational biology · 2021Article
- Cell sorting reveals few novel prokaryote and photosynthetic picoeukaryote associations in the oligotrophic ocean.Environmental microbiology · 2021Article
- Discovery of a small protein factor involved in the coordinated degradation of phycobilisomes in cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Unstable Relationship BetweenFrontiers in plant science · 2021Article
- Critical Role of Light in the Growth and Activity of the Marine NFrontiers in microbiology · 2021Article
- Unusual marine cyanobacteria/haptophyte symbiosis relies on NThe ISME journal · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine planktonic cyanobacteria capable of fixing molecular nitrogen (termed 'diazotrophs') are key in biogeochemical cycling, and the nitrogen fixed is one of the major external sources of nitrogen to the open ocean. Candidatus Atelocyanobacterium thalassa (UCYN-A) is a diazotrophic cyanobacterium known for its widespread geographic distribution in tropical and subtropical oligotrophic oceans, unusually reduced genome and symbiosis with a single-celled prymnesiophyte alga. Recently a novel strain of this organism was also detected in coastal waters sampled from the Scripps Institute of Oceanography pier. We analyzed the metagenome of this UCYN-A2 population by concentrating cells by flow cytometry. Phylogenomic analysis provided strong bootstrap support for the monophyly of UCYN-A (here called UCYN-A1) and UCYN-A2 within the marine Crocosphaera sp. and Cyanothece sp. clade. UCYN-A2 shares 1159 of the 1200 UCYN-A1 protein-coding genes (96.6%) with high synteny, yet the average amino-acid sequence identity between these orthologs is only 86%. UCYN-A2 lacks the same major pathways and proteins that are absent in UCYN-A1, suggesting that both strains can be grouped at the same functional and ecological level. Our results suggest that UCYN-A1 and UCYN-A2 had a common ancestor and diverged after genome reduction. These two variants may reflect adaptation of the host to different niches, which could be coastal and open ocean habitats.
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