ReviewSpermatogenesis2014
Receptors and signaling pathways involved in proliferation and differentiation of Sertoli cells.
Review in Spermatogenesis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- Associations of Bovine Fetal Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells and Germ Cell Marker Expression in Testicular Organoids.Animals : an open access journal from MDPI · 2026Article
- Roles of thyroid and leptin hormones and their crosstalk in male reproductive functions: an updated review.Endocrine · 2025Review
- Review
- 9-cis-retinoic acid signaling in Sertoli cells regulates their immunomodulatory function to control lymphocyte physiology and Treg differentiation.Reproductive biology and endocrinology : RB&E · 2024Article
- Potential role of mitochondria and endoplasmic reticulum in the response elicited by D-aspartate in TM4 Sertoli cells.Frontiers in cell and developmental biology · 2024Article
- Article
- Review
- Immunoregulatory Sertoli Cell Allografts Engineered to Express Human Insulin Survive Humoral-Mediated Rejection.International journal of molecular sciences · 2022Article
- What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us?Frontiers in endocrinology · 2022Review
- Insights into the Regulation on Proliferation and Differentiation of Stem Leydig Cells.Stem cell reviews and reports · 2021Review
- Differentiation of fetal sertoli cells in the adult testis.Reproduction (Cambridge, England) · 2021Article
- The role of estrogen receptors in rat Sertoli cells at different stages of development.Heliyon · 2020Article
- Zika virus dysregulates human Sertoli cell proteins involved in spermatogenesis with little effect on tight junctions.PLoS neglected tropical diseases · 2020Article
- The Sertoli cell: what can we learn from different vertebrate models?Animal reproduction · 2020Article
- Bisphenols Threaten Male Reproductive Health via Testicular Cells.Frontiers in endocrinology · 2020Review
- Pluripotent Cell Models for Gonadal Research.International journal of molecular sciences · 2019Review
- The role of G-protein-coupled membrane estrogen receptor in mouse Leydig cell function-in vivo and in vitro evaluation.Cell and tissue research · 2018Article
- A Human Gonadal Cell Model From Induced Pluripotent Stem Cells.Frontiers in genetics · 2018Article
- In vitro generation of Sertoli-like and haploid spermatid-like cells from human umbilical cord perivascular cells.Stem cell research & therapy · 2017Article
- Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation.Cell discovery · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identification of the hormones and other factors regulating Sertoli cell survival, proliferation, and maturation in neonatal, peripubertal, and pubertal life remains one of the most critical questions in testicular biology. The regulation of Sertoli cell proliferation and differentiation is thought to be controlled by cell-cell junctions and a set of circulating and local hormones and growth factors. In this review, we will focus on receptors and intracellular signaling pathways activated by androgen, follicle-stimulating hormone, thyroid hormone, activin, retinoids, insulin, insulin-like growth factor, relaxin, and estrogen, with special emphasis on estrogen receptors. Estrogen receptors activate intracellular signaling pathways that converge on cell cycle and transcription factors and play a role in the regulation of Sertoli cell proliferation and differentiation.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.