Evidence map›Paper›PMID 25225454›Full record

ArticleComputers & structures2014

Computational modeling of skin: Using stress profiles as predictor for tissue necrosis in reconstructive surgery.

Adrián Buganza Tepole, Arun K Gosain, Ellen Kuhl

Open access · greenAbstract read
In one paragraph

Article in Computers & structures, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 50 citations in OpenAlex.

  1. TowardFrontiers in bioengineering and biotechnology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Personalized Computational Models of Tissue-Rearrangement in the Scalp Predict the Mechanical Stress Signature of Rotation Flaps.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2021
    Article
  9. Preoperative Evaluation of V-Y Flap Design Based on Computer-Aided Analysis.Computational and mathematical methods in medicine · 2020
    Article
  10. Mathematical and computational modelling of skin biophysics: a review.Proceedings. Mathematical, physical, and engineering sciences · 2017
    Review
  11. An Invariant-Based Damage Model for Human and Animal Skins.Annals of biomedical engineering · 2016
    Article
  12. Article
  13. Article
  14. Isogeometric Kirchhoff-Love shell formulations for biological membranes.Computer methods in applied mechanics and engineering · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Adrián Buganza TepoleDepartment of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA.
Arun K GosainDivision of Pediatric Plastic Surgery, Lurie Children's Hospital of Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Ellen KuhlDepartments of Mechanical Engineering, Bioengineering, and Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Stanford University · USNorthwestern University · US

Funding

Physics-based Simulation of Biological Structures(RMI)U54GM072970 · NIGMS · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO · 2004 to 2013
$33.5M
NIGMS NIH HHS U54 GM072970
6 · The paper itself

Abstract

Local skin flaps have revolutionized reconstructive surgery. Mechanical loading is critical for flap survival: Excessive tissue tension reduces blood supply and induces tissue necrosis. However, skin flaps have never been analyzed mechanically. Here we explore the stress profiles of two common flap designs, direct advancement flaps and double back-cut flaps. Our simulations predict a direct correlation between regions of maximum stress and tissue necrosis. This suggests that elevated stress could serve as predictor for flap failure. Our model is a promising step towards computer-guided reconstructive surgery with the goal to minimize stress, accelerate healing, minimize scarring, and optimize tissue use.

Indexed as

Finite element analysisMembranesReconstructive surgerySkinTissue expansionTransverse isotropy

Identifiers

PMID25225454
PMCPMC4162094
OpenAlexW2065183245

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.