Evidence map›Paper›PMID 25225425›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2015

Relationship between male pattern baldness and the risk of aggressive prostate cancer: an analysis of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

Cindy Ke Zhou, Ruth M Pfeiffer, Sean D Cleary, Heather J Hoffman, Paul H Levine, Lisa W Chu, Ann W Hsing, Michael B Cook

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Baldness and Risk of Prostate Cancer in the Health Professionals Follow-up Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Article
  8. Pre-diagnostic Serum Metabolomic Profiling of Prostate Cancer Survival.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Highlights of the university of toronto urology update 2014.Canadian Urological Association journal = Journal de l'Association des urologues du Canada
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Cindy Ke ZhouCindy Ke Zhou, Ruth M. Pfeiffer, and Michael B. Cook, National Cancer Institute, Bethesda, MD; Cindy Ke Zhou, Sean D. Cleary, Heather J. Hoffman, and Paul H. Levine, George Washington University, Washington, DC; and Lisa W. Chu and Ann W. Hsing, Cancer Prevention Institute of California, Fremont, CA.
Ruth M PfeifferCindy Ke Zhou, Ruth M. Pfeiffer, and Michael B. Cook, National Cancer Institute, Bethesda, MD; Cindy Ke Zhou, Sean D. Cleary, Heather J. Hoffman, and Paul H. Levine, George Washington University, Washington, DC; and Lisa W. Chu and Ann W. Hsing, Cancer Prevention Institute of California, Fremont, CA.
Sean D ClearyCindy Ke Zhou, Ruth M. Pfeiffer, and Michael B. Cook, National Cancer Institute, Bethesda, MD; Cindy Ke Zhou, Sean D. Cleary, Heather J. Hoffman, and Paul H. Levine, George Washington University, Washington, DC; and Lisa W. Chu and Ann W. Hsing, Cancer Prevention Institute of California, Fremont, CA.
Heather J HoffmanCindy Ke Zhou, Ruth M. Pfeiffer, and Michael B. Cook, National Cancer Institute, Bethesda, MD; Cindy Ke Zhou, Sean D. Cleary, Heather J. Hoffman, and Paul H. Levine, George Washington University, Washington, DC; and Lisa W. Chu and Ann W. Hsing, Cancer Prevention Institute of California, Fremont, CA.
Paul H LevineCindy Ke Zhou, Ruth M. Pfeiffer, and Michael B. Cook, National Cancer Institute, Bethesda, MD; Cindy Ke Zhou, Sean D. Cleary, Heather J. Hoffman, and Paul H. Levine, George Washington University, Washington, DC; and Lisa W. Chu and Ann W. Hsing, Cancer Prevention Institute of California, Fremont, CA.
Lisa W ChuCindy Ke Zhou, Ruth M. Pfeiffer, and Michael B. Cook, National Cancer Institute, Bethesda, MD; Cindy Ke Zhou, Sean D. Cleary, Heather J. Hoffman, and Paul H. Levine, George Washington University, Washington, DC; and Lisa W. Chu and Ann W. Hsing, Cancer Prevention Institute of California, Fremont, CA.
Ann W HsingCindy Ke Zhou, Ruth M. Pfeiffer, and Michael B. Cook, National Cancer Institute, Bethesda, MD; Cindy Ke Zhou, Sean D. Cleary, Heather J. Hoffman, and Paul H. Levine, George Washington University, Washington, DC; and Lisa W. Chu and Ann W. Hsing, Cancer Prevention Institute of California, Fremont, CA.
Michael B CookCindy Ke Zhou, Ruth M. Pfeiffer, and Michael B. Cook, National Cancer Institute, Bethesda, MD; Cindy Ke Zhou, Sean D. Cleary, Heather J. Hoffman, and Paul H. Levine, George Washington University, Washington, DC; and Lisa W. Chu and Ann W. Hsing, Cancer Prevention Institute of California, Fremont, CA. cookmich@mail.nih.gov.
Parker Institute for Cancer Immunotherapy · US

Funding

Established Investigator Award Anti-Inflammatory Exposures in Cancer PreventionK05CA154337 · NCI · UNIVERSITY OF WASHINGTON · PI WHITE, EMILY · 2011 to 2015
$637k
Intramural NIH HHSNCI NIH HHS K05 CA154337
6 · The paper itself

Abstract

purposeMale pattern baldness and prostate cancer appear to share common pathophysiologic mechanisms. However, results from previous studies that assess their relationship have been inconsistent. Therefore, we investigated the association of male pattern baldness at age 45 years with risks of overall and subtypes of prostate cancer in a large, prospective cohort—the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.

methodsWe included 39,070 men from the usual care and screening arms of the trial cohort who had no cancer diagnosis (excluding nonmelanoma skin cancer) at the start of follow-up and recalled their hair-loss patterns at age 45 years. Hazard ratios (HRs) and 95% CIs were estimated by using Cox proportional hazards regression models with age as the time metric.

resultsDuring follow-up (median, 2.78 years), 1,138 incident prostate cancer cases were diagnosed, 571 of which were aggressive (biopsy Gleason score ≥ 7, and/or clinical stage III or greater, and/or fatal). Compared with no baldness, frontal plus moderate vertex baldness at age 45 years was not significantly associated with overall (HR, 1.19; 95% CI, 0.98 to 1.45) or nonaggressive (HR, 0.97; 95% CI, 0.72 to 1.30) prostate cancer risk but was significantly associated with increased risk of aggressive prostate cancer (HR, 1.39; 95% CI, 1.07 to 1.80). Adjustment for covariates did not substantially alter these estimates. Other classes of baldness were not significantly associated with overall or subtypes of prostate cancer.

conclusionOur analysis indicates that frontal plus moderate vertex baldness at age 45 years is associated with an increased risk of aggressive prostate cancer and supports the possibility of common pathophysiologic mechanisms.

Indexed as

AgedAlopeciaBiopsyEarly Detection of CancerFollow-Up StudiesHumansIncidenceMaleMass ScreeningMiddle AgedNeoplasm GradingNeoplasm StagingProportional Hazards ModelsProspective StudiesProstateProstatic Neoplasms

Identifiers

PMID25225425
PMCPMC4314593
OpenAlexW2157830175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.