ArticleJournal of bacteriology2014
Sporulation during growth in a gut isolate of Bacillus subtilis.
Article in Journal of bacteriology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Examining the Gastrointestinal and Immunomodulatory Effects of the Novel ProbioticInternational journal of molecular sciences · 2021Trial
- 4-Hydroxy-3-Methyl-2-Alkenylquinoline Disrupts Temporospatial Control of Flagellar Assembly and Induces Transcriptomic Remodeling inMolecules (Basel, Switzerland) · 2026Article
- Molecular insights into the promiscuous ApThe Journal of biological chemistry · 2026Article
- Characterization ofBioscience of microbiota, food and health · 2026Article
- Effects of bacteriophages on gut microbiome functionality.Gut microbes · 2025Review
- Modulation of the Sporulation Dynamics in the Plant-Probiotic Bacillus velezensis 83 via Carbon and Quorum-Sensing Metabolites.Probiotics and antimicrobial proteins · 2025Article
- The megaplasmid pCER270 ofApplied and environmental microbiology · 2024Article
- The rise and future of CRISPR-based approaches for high-throughput genomics.FEMS microbiology reviews · 2024Review
- Review
- Clostridioides difficile Sporulation.Advances in experimental medicine and biology · 2024Review
- Changes in community structures and functions of the gut microbiomes of deep-sea cold seep mussels during in situ transplantation experiment.Animal microbiome · 2023Article
- Oral vaccination of fish against vibriosis using spore-display technology.Frontiers in immunology · 2022Article
- Deletion of Rap-Phr systems in Bacillus subtilis influences in vitro biofilm formation and plant root colonization.MicrobiologyOpen · 2021Article
- Pervasive prophage recombination occurs during evolution of spore-forming Bacilli.The ISME journal · 2021Article
- Impact of Rap-Phr system abundance on adaptation of Bacillus subtilis.Communications biology · 2021Article
- CD25890, a conserved protein that modulates sporulation initiation in Clostridioides difficile.Scientific reports · 2021Article
- Rampant loss of social traits during domestication of a Bacillus subtilis natural isolate.Scientific reports · 2020Article
- A spore quality-quantity tradeoff favors diverse sporulation strategies in Bacillus subtilis.The ISME journal · 2020Article
- Impact of spatial proximity on territoriality among human skin bacteria.NPJ biofilms and microbiomes · 2020Article
- Full-repertoire comparison of the microscopic objects composing the human gut microbiome with sequenced and cultured communities.Journal of microbiology (Seoul, Korea) · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sporulation by Bacillus subtilis is a cell density-dependent response to nutrient deprivation. Central to the decision of entering sporulation is a phosphorelay, through which sensor kinases promote phosphorylation of Spo0A. The phosphorelay integrates both positive and negative signals, ensuring that sporulation, a time- and energy-consuming process that may bring an ecological cost, is only triggered should other adaptations fail. Here we report that a gastrointestinal isolate of B. subtilis sporulates with high efficiency during growth, bypassing the cell density, nutritional, and other signals that normally make sporulation a post-exponential-phase response. Sporulation during growth occurs because Spo0A is more active per cell and in a higher fraction of the population than in a laboratory strain. This in turn, is primarily caused by the absence from the gut strain of the genes rapE and rapK, coding for two aspartyl phosphatases that negatively modulate the flow of phosphoryl groups to Spo0A. We show, in line with recent results, that activation of Spo0A through the phosphorelay is the limiting step for sporulation initiation in the gut strain. Our results further suggest that the phosphorelay is tuned to favor sporulation during growth in gastrointestinal B. subtilis isolates, presumably as a form of survival and/or propagation in the gut environment.
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