ArticleInfection and immunity2014
Cellular requirements for systemic control of Salmonella enterica serovar Typhimurium infections in mice.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Comprehensive analyses of pathogen loads and immune responses alongside the gastrointestinal tract upon long-term Salmonella Typhimurium-infection of clinically resistant mice.European journal of microbiology & immunology · 2026Article
- LCMV-mediated loss of virtual memory CD8 T cells yields a functionally enhanced T cell subset.iScience · 2025Article
- Coordinated Regulation of Extrafollicular B Cell Responses by IL-12 and IFNγ.Immunological reviews · 2025Review
- The role of tissue resident memory CD4 T cells in Salmonella infection: Implications for future vaccines.Vaccine · 2023Review
- Vaccine-induced inflammation and inflammatory monocytes promote CD4+ T cell-dependent immunity against murine salmonellosis.PLoS pathogens · 2023Article
- Article
- CCL17-expressing dendritic cells in the intestine are preferentially infected by Salmonella but CCL17 plays a redundant role in systemic dissemination.Immunity, inflammation and disease · 2021Article
- The determination of antibacterial mode for cationic lipopeptides brevibacillins against Salmonella typhimurium by quantum chemistry calculation.Applied microbiology and biotechnology · 2021Article
- CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD.PLoS pathogens · 2021Article
- Failure of CD4 T Cell-Deficient Hosts To Control Chronic NontyphoidalInfection and immunity · 2020Article
- Regulatory T cells control the dynamic and site-specific polarization of total CD4 T cells following Salmonella infection.Mucosal immunology · 2020Article
- Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection.Immunity · 2020Article
- The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules.Cell host & microbe · 2020Article
- Bacteria That Cause Enteric Diseases Stimulate Distinct Humoral Immune Responses.Frontiers in immunology · 2020Review
- Innate Activation of IFN-γ-iNOS Axis During Infection WithFrontiers in immunology · 2020Article
- Diet-induced obese mice exhibit altered immune responses to early Salmonella Typhimurium oral infection.Journal of microbiology (Seoul, Korea) · 2018Article
- MAIT cells protect against pulmonary Legionella longbeachae infection.Nature communications · 2018Article
- HU-Lacking Mutants ofFrontiers in microbiology · 2018Article
- Enteric Helminths Promote Salmonella Coinfection by Altering the Intestinal Metabolome.The Journal of infectious diseases · 2017Article
- U-Omp19 fromFrontiers in immunology · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rational design of vaccines requires an understanding of the contributions of individual immune cell subsets to immunity. With this understanding, targeted vaccine delivery approaches and adjuvants can be developed to maximize vaccine efficiency and to minimize side effects (S. H. E. Kaufmann et al., Immunity 33:555-577, 2010; T. Ben-Yedidia and R. Arnon, Hum. Vaccines 1:95-101, 2005). We have addressed the contributions of different immune cell subsets and their ability to contribute to the control and clearance of the facultative intracellular pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium) in a murine model. Using a systematic and reproducible model of experimental attenuated S. Typhimurium infection, we show that distinct lymphocyte deficiencies lead to one of four different infection outcomes: clearance, chronic infection, early death, or late death. Our study demonstrates a high level of functional redundancy in the ability of different lymphocyte subsets to provide interferon gamma (IFN-γ), a critical cytokine in Salmonella immunity. Whereas early control of the infection was entirely dependent on IFN-γ but not on any particular lymphocyte subset, clearance of the infection critically required CD4(+) T cells but appeared to be independent of IFN-γ. These data reinforce the idea of a bimodal immune response against Salmonella: an early T cell-independent but IFN-γ-dependent phase and a late T cell-dependent phase that may be IFN-γ independent.
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Registered trials
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