Evidence map›Paper›PMID 25225182›Full record

ArticleJournal of pediatric psychology

Opioid misuse behaviors in adolescents and young adults in a hematology/oncology setting.

Jennifer Harman Ehrentraut, Kathleen Danielle Kern, Sarah A Long, Angel Qi An, Lane G Faughnan, Doralina L Anghelescu

Registry-linked trialAbstract read
In one paragraph

Article in Journal of pediatric psychology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06940570 (A Randomized Single Center Trial to Determine the Efficacy of Methadone as a First Line Agent in the Reduction and Treatment of Pain in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation), which is not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06940570 phase3suspendednot on this map

A Randomized Single Center Trial to Determine the Efficacy of Methadone as a First Line Agent in the Reduction and Treatment of Pain in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2028 to 2029Enrolled60ConditionsLeukemia, Aplastic Anemia, Bone Marrow Failure Syndromes, SCIDArmsPCA plus methadone (Experimental), PCA Alone (SOC)
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. A systematic review of assessment approaches to predict opioid misuse in people with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  2. Opioid use and misuse in children, adolescents, and young adults with cancer: a systematic review of the literature.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
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  17. Chronic opioid therapy in long-term cancer survivors.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jennifer Harman EhrentrautDepartment of Psychology, Division of Anesthesia, Department of Pediatric Medicine, and Department of Biostatistics, St. Jude Children's Research Hospital Jennifer.ehrentraut@stjude.org.
Kathleen Danielle KernDepartment of Psychology, Division of Anesthesia, Department of Pediatric Medicine, and Department of Biostatistics, St. Jude Children's Research Hospital.
Sarah A LongDepartment of Psychology, Division of Anesthesia, Department of Pediatric Medicine, and Department of Biostatistics, St. Jude Children's Research Hospital.
Angel Qi AnDepartment of Psychology, Division of Anesthesia, Department of Pediatric Medicine, and Department of Biostatistics, St. Jude Children's Research Hospital.
Lane G FaughnanDepartment of Psychology, Division of Anesthesia, Department of Pediatric Medicine, and Department of Biostatistics, St. Jude Children's Research Hospital.
Doralina L AnghelescuDepartment of Psychology, Division of Anesthesia, Department of Pediatric Medicine, and Department of Biostatistics, St. Jude Children's Research Hospital.

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
PROFESSIONAL ONCOLOGY EDUCATION PROGRAMR25CA023944 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SUZANNE A. GRONEMEYER · 1986 to 2026
$8.3M
NCI NIH HHS 5P30CA021765NCI NIH HHS 5R25CA02394NCI NIH HHS P30 CA021765NCI NIH HHS R25 CA023944
6 · The paper itself

Abstract

objectiveTo describe the occurrence and psychosocial correlates of aberrant opioid-associated behavior (AOB) in adolescent and young adult (AYA) hematology and oncology patients prescribed opioid therapy.

methodsStructured retrospective chart reviews were conducted for AYA patients (N = 398) accepted for active treatment at a large pediatric hematology/oncology institution over a 17-month period. Opioid therapy was documented in the records of 94 out of the 398 patients. The records of those 94 patients were further reviewed to identify documented AOB and documented correlates of AOB.

resultsOf the 94 patients prescribed opioid therapy, 11.7% exhibited AOB. At least one psychosocial risk factor was identified in 90.9% of patients with AOB. Concurrent use of multiple opioids was significantly associated with AOB (p = .003).

conclusionsHematology/oncology AYA patients may exhibit AOB despite a legitimate clinical indication for opioid therapy. Clinicians should consider young patients' psychosocial risk factors when using opioid therapy.

Indexed as

AdolescentAdolescent BehaviorAdultAnalgesics, OpioidAnemia, Sickle CellChildComorbidityFemaleHematologyHumansMaleNeoplasmsOpioid-Related DisordersPainRetrospective StudiesRisk FactorsAnalgesics, Opioidadherencecancer and oncologydrug abuse and exposurehematology

Identifiers

PMID25225182
PMCPMC4201768

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.