ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2014
Volume transmission signalling via astrocytes.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- Impact of distinct neurotransmitter release modes on neuronal signaling.Molecular psychiatry · 2026Review
- Estradiol Mediates Astrocyte-Neuron Communication in the Hippocampus.Molecular neurobiology · 2025Article
- Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IPProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cholinergic signaling to CA1 astrocytes controls fear extinction.Science advances · 2025Article
- Characterization of the Astrocyte Calcium Response to Norepinephrine in the Ventral Tegmental Area.Cells · 2024Article
- A conceptual framework for astrocyte function.Nature neuroscience · 2023Review
- Cholinergic modulation of sensory processing in awake mouse cortex.Scientific reports · 2021Article
- Receptor-Receptor Interactions and Glial Cell Functions with a Special Focus on G Protein-Coupled Receptors.International journal of molecular sciences · 2021Review
- NMDARs, Coincidence Detectors of Astrocytic and Neuronal Activities.International journal of molecular sciences · 2021Review
- Neuromodulation of Astrocytic KInternational journal of molecular sciences · 2021Article
- Astrocytes, Noradrenaline, α1-Adrenoreceptors, and Neuromodulation: Evidence and Unanswered Questions.Frontiers in cellular neuroscience · 2021Review
- Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement.Frontiers in neural circuits · 2021Article
- Difference in Performance of EPI Pigs Fed Either Lipase-Predigested or Creon®-Supplemented Semielemental Diet.BioMed research international · 2021Article
- Making sense of astrocytic calcium signals - from acquisition to interpretation.Nature reviews. Neuroscience · 2020Review
- Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep-wake states.Communications biology · 2020Article
- Astrocytes modulate sensory-evoked neuronal network activity.Nature communications · 2020Article
- Astrocytes-The Ultimate Effectors of Long-Range Neuromodulatory Networks?Frontiers in cellular neuroscience · 2020Article
- Effects of Methamphetamine Self-Administration and Extinction on Astrocyte Structure and Function in the Nucleus Accumbens Core.Neuroscience · 2019Article
- Astrocytes in the cerebral cortex play a role in the spontaneous motor recovery following experimental striatal hemorrhage.Neural regeneration research · 2018Article
- Environmental Enrichment Upregulates Striatal Synaptic Vesicle-Associated Proteins and Improves Motor Function.Frontiers in neurology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influence of astrocytes on synaptic function has been increasingly studied, owing to the discovery of both gliotransmission and morphological ensheathment of synapses. While astrocytes exhibit at best modest membrane potential fluctuations, activation of G-protein coupled receptors (GPCRs) leads to a prominent elevation of intracellular calcium which has been reported to correlate with gliotransmission. In this review, the possible role of astrocytic GPCR activation is discussed as a trigger to promote synaptic plasticity, by affecting synaptic receptors through gliotransmitters. Moreover, we suggest that volume transmission of neuromodulators could be a biological mechanism to activate astrocytic GPCRs and thereby to switch synaptic networks to the plastic mode during states of attention in cerebral cortical structures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.