ArticleNeuroImage2014
Mapping mean axon diameter and axonal volume fraction by MRI using temporal diffusion spectroscopy.
Article in NeuroImage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.
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Who cites it
73 citing papers in PubMed, 1 synthesis or guideline pooled it, 132 citations in OpenAlex.
- Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 2-Ex vivo imaging: Added value and acquisition.Magnetic resonance in medicine · 2025Guideline
- Physics-Assisted Deep Learning Denoising for Stabilized IMPULSED dMRI Microenvironment Parameter Fitting.ArXiv · 2026Article
- Investigating the Sensitivity of the Diffusion MRI Signal to Magnetization Transfer and Permeability via Monte-Carlo Simulations.Magnetic resonance in medicine · 2026Article
- Quantifying Transmembrane Water Exchange by Diffusion NMR Methods: From Yeast Cells to Optic Nerve Ex Vivo.NMR in biomedicine · 2026Article
- Progressive axonal degeneration in white matter pathways traversing peritumoral penumbra in frontotemporal glioma.Computational diffusion MRI. CDMRI (Workshop) · 2026Article
- Evaluation of diffusion time-dependent changes in radial diffusivity as a surrogate for axon diameter.Magnetic resonance in medicine · 2025Article
- Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 1: In vivo small-animal imaging.Magnetic resonance in medicine · 2025Review
- In vivo mapping of cellular resolution neuropathology in brain ischemia with diffusion MRI.Science advances · 2024Article
- Identification of diffusion, kurtosis, and propagator MRI markers of Alzheimer's disease pathology in post-mortem human tissue.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Time-dependent diffusion MRI using multiple stimulated echoes.Magnetic resonance in medicine · 2023Article
- Temporal Diffusion Ratio (TDR) for imaging restricted diffusion: Optimisation and pre-clinical demonstration.NeuroImage · 2023Article
- Mapping Human Brain Pathways: Challenges and Opportunities in the Integration of Scales.Brain, behavior and evolution · 2023Review
- Estimating axon radius using diffusion-relaxation MRI: calibrating a surface-based relaxation model with histology.Frontiers in neuroscience · 2023Article
- Selective Cell Size MRI Differentiates Brain Tumors from Radiation Necrosis.Cancer research · 2022Article
- Review
- Long-Term Changes in Axon Calibers after Injury: Observations on the Mouse Corticospinal Tract.International journal of molecular sciences · 2022Article
- Review
- The present and the future of microstructure MRI: From a paradigm shift to normal science.Journal of neuroscience methods · 2021Review
- A simple estimate of axon size with diffusion MRI.NeuroImage · 2021Article
- MRI-cytometry: Mapping nonparametric cell size distributions using diffusion MRI.Magnetic resonance in medicine · 2021Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Mapping mean axon diameter and intra-axonal volume fraction may have significant clinical potential because nerve conduction velocity is directly dependent on axon diameter, and several neurodegenerative diseases affect axons of specific sizes and alter axon counts. Diffusion-weighted MRI methods based on the pulsed gradient spin echo (PGSE) sequence have been reported to be able to assess axon diameter and volume fraction non-invasively. However, due to the relatively long diffusion times used, e.g. >20ms, the sensitivity to small axons (diameter<2μm) is low, and the derived mean axon diameter has been reported to be overestimated. In the current study, oscillating gradient spin echo (OGSE) diffusion sequences with variable frequency gradients were used to assess rat spinal white matter tracts with relatively short effective diffusion times (1-5ms). In contrast to previous PGSE-based methods, the extra-axonal diffusion cannot be modeled as hindered (Gaussian) diffusion when short diffusion times are used. Appropriate frequency-dependent rates are therefore incorporated into our analysis and validated by histology-based computer simulation of water diffusion. OGSE data were analyzed to derive mean axon diameters and intra-axonal volume fractions of rat spinal white matter tracts (mean axon diameter of ~1.27-5.54μm). The estimated values were in good agreement with histology, including the small axon diameters (<2.5μm). This study establishes a framework for the quantification of nerve morphology using the OGSE method with high sensitivity to small axons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.