ArticleEuropean radiology2015
Heterogeneity of triple-negative breast cancer: mammographic, US, and MR imaging features according to androgen receptor expression.
Article in European radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Advances of androgen receptor in triple-negative breast cancer: from molecular mechanisms to clinical applications.Discover oncology · 2025Review
- The impact of radiogenomics on breast cancer.American journal of cancer research · 2025Review
- Correlation of androgen receptor with ultrasound, clinicopathological features and clinical outcomes in breast cancer.Insights into imaging · 2023Article
- Malignant Apocrine Lesions of the Breast: Multimodality Imaging Findings and Biologic Features.Journal of breast cancer · 2022Article
- Characterization of breast cancer subtypes based on quantitative assessment of intratumoral heterogeneity using dynamic contrast-enhanced and diffusion-weighted magnetic resonance imaging.European radiology · 2022Article
- Review
- Imaging features of triple-negative breast cancers according to androgen receptor status.European journal of radiology · 2019Article
- Combining Diagnostic Imaging and Pathology for Improving Diagnosis and Prognosis of Cancer.Contrast media & molecular imaging · 2019Review
- Role of DCE-MR in predicting breast cancer subtypes.La Radiologia medica · 2018Article
- Contrast Enhancement on Cone-Beam Breast-CT for Discrimination of Breast Cancer Immunohistochemical Subtypes.Translational oncology · 2017Article
- Investigation of Association Between Borderline Pancreatic Head Cancer and Glucose Uptake by Using Positron-Emission Tomographic Studies.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Clinical predictors of pathological complete response to neoadjuvant chemotherapy in triple-negative breast cancer.Oncology letters · 2017Article
- Cone-beam Breast Computed Tomography: CT Density Does Not Reflect Proliferation Potential and Receptor Expression of Breast Carcinoma.Translational oncology · 2017Article
- Immunohistochemical Subtypes of Breast Cancer: Correlation with Clinicopathological and Radiological Factors.Iranian journal of radiology : a quarterly journal published by the Iranian Radiological Society · 2016Article
- The Changing World of Breast Cancer: A Radiologist's Perspective.Investigative radiology · 2015Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOur aim was to determine whether triple-negative breast cancers (TNBCs) with and without androgen receptor (AR) expression have distinguishing imaging features on mammography, breast ultrasound (US), and magnetic resonance (MR) imaging.
methodsAR expression was assessed immunohistochemically in 125 patients with TNBC from a consecutive series of 1,086 operable invasive breast cancers. Two experienced radiologists blinded to clinicopathological findings reviewed all imaging studies in consensus using the BI-RADS lexicon. The imaging and pathological features of 33 AR-positive TNBCs were compared with those of 92 AR-negative TNBCs.
resultsThe presence of mammographic calcifications with or without a mass (p < 0.001), non-mass enhancement on MR imaging (p < 0.001), and masses with irregular shape or spiculated margins on US (p < 0.001 and p = 0.002) and MR imaging (p = 0.001 and p < 0.001) were significantly associated with AR-positive TNBC. Compared with AR-negative TNBC, AR-positive TNBC was more likely to have a ductal carcinoma in situ component (59.8% vs. 90.9%, p = 0.001) and low Ki-67 expression (30.4% vs. 51.5%, p = 0.030).
conclusionAR-positive and AR-negative TNBCs have different imaging features, and certain imaging findings can be useful to predict AR status in TNBC. KEY POINTS: • Triple-negative breast cancers have distinguishing imaging features according to AR expression. • AR-positive TNBC is associated with calcifications, spiculated masses, and non-mass enhancement. • Multimodality imaging can help predict androgen receptor status in TNBC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.