ArticleBiology direct2014
Mycobacteriophage-drived diversification of Mycobacterium abscessus.
Article in Biology direct, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Advances in mycobacteriophage research: from lytic mechanisms to one health applications.Frontiers in cellular and infection microbiology · 2026Review
- A nontuberculous mycobacterium could solve the mystery of the lady from the Franciscan church in Basel, Switzerland.BMC biology · 2023Article
- A Review on Mycobacteriophages: From Classification to Applications.Pathogens (Basel, Switzerland) · 2022Review
- Article
- The Prophage and Plasmid Mobilome as a Likely Driver of Mycobacterium abscessus Diversity.mBio · 2021Article
- Phage Therapy for Mycobacterium Abscessus and Strategies to Improve Outcomes.Microorganisms · 2021Review
- ComprehensiveMicrobial genomics · 2021Article
- Genome Sequence of Mycobacterium abscessus Phage phiT46-1.Microbiology resource announcements · 2021Article
- Considerations for Phage Therapy AgainstFrontiers in microbiology · 2020Review
- Mycobacteriophages.Microbiology spectrum · 2018Review
- Genomic Comparisons Reveal Microevolutionary Differences inFrontiers in microbiology · 2017Article
- Genome Sequences of Mycobacteriophages AlanGrant, Baee, Corofin, OrangeOswald, and Vincenzo, New Members of Cluster B.Genome announcements · 2015Article
- Isolation and complete genome sequence of a novel virulent mycobacteriophage, CASbig.Virologica Sinica · 2015Article
- Smooth Tubercle Bacilli: Neglected Opportunistic Tropical Pathogens.Frontiers in public health · 2015Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMycobacterium abscessus is an emerging opportunistic pathogen which diversity was acknowledged by the recent description of two subspecies accommodating M. abscessus, Mycobacterium bolletii and Mycobacterium massiliense isolates.
resultsHere, genome analysis found 1-8 prophage regions in 47/48 M. abscessus genomes ranging from small prophage-like elements to complete prophages. A total of 20,304 viral and phage proteins clustered into 853 orthologous groups. Phylogenomic and phylogenetic analyses based on prophage region homology found three main clusters corresponding to M. abscessus, M. bolletii and M. massiliense. Analysing 135 annotated Tape Measure Proteins found thirteen clusters and four singletons, suggesting that at least 17 mycobacteriophages had infected M. abscessus during its evolution. The evolutionary history of phages differed from that of their mycobacterial hosts. In particular, 33 phage-related proteins have been horizontally transferred within M. abscessus genomes. They comprise of an integrase, specific mycobacteriophage proteins, hypothetical proteins and DNA replication and metabolism proteins. Gene exchanges, loss and gains which occurred in M. abscessus genomes have been driven by several mycobacteriophages.
conclusionsThis analysis of phage-mycobacterium co-evolution suggests that mycobacteriophages are playing a key-role in the on-going diversification of M. abscessus. REVIEWERS: This article was reviewed by Eric Bapteste, Patrick Forterre and Eugene Koonin.
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